The effect of Danazol in sexual precocity

P. A. Lee, R. G. Thompson, C. J. Migeon, R. M. Blizzard

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effect of Danazol, a synthetic 2,3 isoxazol derivative of 17 alpha ethinyl testosterone, was assessed in three girls and two boys with sexual precocity. Progression of sexual development ceased during administration of Danazol; the effect upon growth rate and skeletal maturation was equivocal. Serum estrogen and progesterone concentrations in the girls were lower during treatment; serum testosterone and dehydroepiandrosterone levels in the boys were also lower. Serum and urinary luteinizing hormone concentrations were inconsistently suppressed. No effect upon follicle stimulating hormone levels could be demonstrated. Although Danazol appears to inhibit sexual development, this study indicates that the pituitary gonadal axis is not completely suppressed. Growth rate is not reverted to normal, and virilization may occur among girls. Because undesirable side effects may outweigh desirable results, careful consideration is recommended before Danazol is prescribed in the management of sexual precocity.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalJohns Hopkins Medical Journal
Volume137
Issue number6
StatePublished - Dec 1 1975

Fingerprint

Danazol
Sexual Development
Epitestosterone
Serum
Virilism
Dehydroepiandrosterone
Follicle Stimulating Hormone
Growth
Luteinizing Hormone
Progesterone
Testosterone
Estrogens
Sexual precocity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, P. A., Thompson, R. G., Migeon, C. J., & Blizzard, R. M. (1975). The effect of Danazol in sexual precocity. Johns Hopkins Medical Journal, 137(6), 265-269.
Lee, P. A. ; Thompson, R. G. ; Migeon, C. J. ; Blizzard, R. M. / The effect of Danazol in sexual precocity. In: Johns Hopkins Medical Journal. 1975 ; Vol. 137, No. 6. pp. 265-269.
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Lee, PA, Thompson, RG, Migeon, CJ & Blizzard, RM 1975, 'The effect of Danazol in sexual precocity', Johns Hopkins Medical Journal, vol. 137, no. 6, pp. 265-269.

The effect of Danazol in sexual precocity. / Lee, P. A.; Thompson, R. G.; Migeon, C. J.; Blizzard, R. M.

In: Johns Hopkins Medical Journal, Vol. 137, No. 6, 01.12.1975, p. 265-269.

Research output: Contribution to journalArticle

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AB - The effect of Danazol, a synthetic 2,3 isoxazol derivative of 17 alpha ethinyl testosterone, was assessed in three girls and two boys with sexual precocity. Progression of sexual development ceased during administration of Danazol; the effect upon growth rate and skeletal maturation was equivocal. Serum estrogen and progesterone concentrations in the girls were lower during treatment; serum testosterone and dehydroepiandrosterone levels in the boys were also lower. Serum and urinary luteinizing hormone concentrations were inconsistently suppressed. No effect upon follicle stimulating hormone levels could be demonstrated. Although Danazol appears to inhibit sexual development, this study indicates that the pituitary gonadal axis is not completely suppressed. Growth rate is not reverted to normal, and virilization may occur among girls. Because undesirable side effects may outweigh desirable results, careful consideration is recommended before Danazol is prescribed in the management of sexual precocity.

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Lee PA, Thompson RG, Migeon CJ, Blizzard RM. The effect of Danazol in sexual precocity. Johns Hopkins Medical Journal. 1975 Dec 1;137(6):265-269.