The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves

Luke H. Herbertson, Keefe B. Manning, Varun Reddy, Arnold A. Fontaine, John M. Tarbell, Steven Deutsch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and aim of the study: Mechanical heart valves (MHVs) are known to induce cavitation during closure and rebound. Cavitation may lead to blood element damage and stable bubble formation, with the latter introducing emboli into the cranial circulation and increasing the risk of stroke. Previous research has suggested that CO2 is the primary blood gas involved in stable bubble growth, due to its high solubility compared to that of oxygen or nitrogen. The primary objective of this study is to determine the role that CO2 plays in MHV-induced cavitation bubble formation. Methods: Degassed water (5 ppm) was supplemented with CO2 at partial pressures of 0, 40 and 100 mmHg. Cavitation was visualized using high-speed videography for 29 mm Björk-Shiley Monostrut and Medtronic Hall MHVs in the mitral position. Experimental parameters (heart rate, systolic duration, and left ventricular pressure) were adjusted to provide dp/dt values of 500, 2,500 and 4,500 mmHg/s. High-frequency pressure fluctuations of cavitation bubble collapse were detected using a hydrophone. Results: Root-mean square (RMS) values were calculated to quantify the cavitation intensity for both MHVs at the three loading conditions. The images of cavitation bubble formation and collapse were correlated to their respective RMS values. This study revealed no statistical difference between the cavitation intensities produced by either of the MHVs for the range of CO2-supplemented degassed water tested. For example, at the most physiologic loading condition of 2,500 mmHg/s, the RMS values for the Björk-Shiley Monostrut valve in degassed water containing 0 and 100 mmHg CO2 were 32.7 ± 3.5 and 34.3 ± 6.1 mmHg, respectively. Conclusion: The results of this in-vitro study show that, despite affecting stable bubble growth, the presence and quantity of dissolved CO2 does not affect the intensity of the cavitation events occurring during impact of the valve occluder with its housing. Therefore, the role of CO2 is limited to stable bubble development.

Original languageEnglish (US)
Pages (from-to)835-842
Number of pages8
JournalJournal of Heart Valve Disease
Volume14
Issue number6
StatePublished - Nov 1 2005

Fingerprint

Heart Valves
Carbon Dioxide
Water
Partial Pressure
Ventricular Pressure
Growth
Embolism
Solubility
Nitrogen
Heart Rate
Gases
Stroke
Oxygen
Pressure
Research

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Herbertson, Luke H. ; Manning, Keefe B. ; Reddy, Varun ; Fontaine, Arnold A. ; Tarbell, John M. ; Deutsch, Steven. / The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves. In: Journal of Heart Valve Disease. 2005 ; Vol. 14, No. 6. pp. 835-842.
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abstract = "Background and aim of the study: Mechanical heart valves (MHVs) are known to induce cavitation during closure and rebound. Cavitation may lead to blood element damage and stable bubble formation, with the latter introducing emboli into the cranial circulation and increasing the risk of stroke. Previous research has suggested that CO2 is the primary blood gas involved in stable bubble growth, due to its high solubility compared to that of oxygen or nitrogen. The primary objective of this study is to determine the role that CO2 plays in MHV-induced cavitation bubble formation. Methods: Degassed water (5 ppm) was supplemented with CO2 at partial pressures of 0, 40 and 100 mmHg. Cavitation was visualized using high-speed videography for 29 mm Bj{\"o}rk-Shiley Monostrut and Medtronic Hall MHVs in the mitral position. Experimental parameters (heart rate, systolic duration, and left ventricular pressure) were adjusted to provide dp/dt values of 500, 2,500 and 4,500 mmHg/s. High-frequency pressure fluctuations of cavitation bubble collapse were detected using a hydrophone. Results: Root-mean square (RMS) values were calculated to quantify the cavitation intensity for both MHVs at the three loading conditions. The images of cavitation bubble formation and collapse were correlated to their respective RMS values. This study revealed no statistical difference between the cavitation intensities produced by either of the MHVs for the range of CO2-supplemented degassed water tested. For example, at the most physiologic loading condition of 2,500 mmHg/s, the RMS values for the Bj{\"o}rk-Shiley Monostrut valve in degassed water containing 0 and 100 mmHg CO2 were 32.7 ± 3.5 and 34.3 ± 6.1 mmHg, respectively. Conclusion: The results of this in-vitro study show that, despite affecting stable bubble growth, the presence and quantity of dissolved CO2 does not affect the intensity of the cavitation events occurring during impact of the valve occluder with its housing. Therefore, the role of CO2 is limited to stable bubble development.",
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The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves. / Herbertson, Luke H.; Manning, Keefe B.; Reddy, Varun; Fontaine, Arnold A.; Tarbell, John M.; Deutsch, Steven.

In: Journal of Heart Valve Disease, Vol. 14, No. 6, 01.11.2005, p. 835-842.

Research output: Contribution to journalArticle

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AU - Manning, Keefe B.

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