The effect of hydrocortisone on lamb lung function

J. W.C. Johnson, H. S. Limb, K. Kearney, H. Abbey, G. H. Brumley, C. J. Migeon, Peter Lee, R. Scott

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.

Original languageEnglish (US)
Pages (from-to)413-420
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume26
Issue number8
StatePublished - Oct 26 1981

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Hydrocortisone
Lung
Surface Tension
Macaca mulatta
Phosphatidylcholines
Surface-Active Agents
Glucocorticoids

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Johnson, J. W. C., Limb, H. S., Kearney, K., Abbey, H., Brumley, G. H., Migeon, C. J., ... Scott, R. (1981). The effect of hydrocortisone on lamb lung function. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 26(8), 413-420.
Johnson, J. W.C. ; Limb, H. S. ; Kearney, K. ; Abbey, H. ; Brumley, G. H. ; Migeon, C. J. ; Lee, Peter ; Scott, R. / The effect of hydrocortisone on lamb lung function. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1981 ; Vol. 26, No. 8. pp. 413-420.
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Johnson, JWC, Limb, HS, Kearney, K, Abbey, H, Brumley, GH, Migeon, CJ, Lee, P & Scott, R 1981, 'The effect of hydrocortisone on lamb lung function', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 26, no. 8, pp. 413-420.

The effect of hydrocortisone on lamb lung function. / Johnson, J. W.C.; Limb, H. S.; Kearney, K.; Abbey, H.; Brumley, G. H.; Migeon, C. J.; Lee, Peter; Scott, R.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 26, No. 8, 26.10.1981, p. 413-420.

Research output: Contribution to journalArticle

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Johnson JWC, Limb HS, Kearney K, Abbey H, Brumley GH, Migeon CJ et al. The effect of hydrocortisone on lamb lung function. Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1981 Oct 26;26(8):413-420.