The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit: An experimental study

Abhijeet Joshi, Edward Vresilovic, Michele Marcolongo, Anthony Lowman, Andrew Karduna

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Over five million Americans suffer from lower back pain, making it the leading cause of lost workdays in the United States. Origin of the low back is often the degenerated lumbar intervertebral disc. Current treatment options such as discectomy and /or spinal fusion fail to restore normal biomechanics of the spine. We are investing replacing the nucleus pulposus of the intervertebral disc with polymeric hydrogel implant. The present study reports the effect of polymeric hydrogel implant on the mechanical behavior of the human cadaveric lumbar functional spinal unit in axial compression. The implantation of the hydrogel implant in the denucleated specimen significantly restores the compressive behavior of the functional spinal unit This implantation of a hydrogel nucleus replacement shows promise in restoring the normal biomechanics of the spine.

Original languageEnglish (US)
Title of host publicationBioengineering, Proceedings of the Northeast Conference
EditorsS. Reisman, R. Foulds, B. Mantilla
Pages211-212
Number of pages2
StatePublished - 2003
EventProceedings of the IEEE 29th Annual Northeast Bioengineering Conference - Newark, NJ, United States
Duration: Mar 22 2003Mar 23 2003

Other

OtherProceedings of the IEEE 29th Annual Northeast Bioengineering Conference
CountryUnited States
CityNewark, NJ
Period3/22/033/23/03

Fingerprint

Hydrogel
Hydrogels
Biomechanics
Axial compression
Fusion reactions

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

Joshi, A., Vresilovic, E., Marcolongo, M., Lowman, A., & Karduna, A. (2003). The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit: An experimental study. In S. Reisman, R. Foulds, & B. Mantilla (Eds.), Bioengineering, Proceedings of the Northeast Conference (pp. 211-212)
Joshi, Abhijeet ; Vresilovic, Edward ; Marcolongo, Michele ; Lowman, Anthony ; Karduna, Andrew. / The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit : An experimental study. Bioengineering, Proceedings of the Northeast Conference. editor / S. Reisman ; R. Foulds ; B. Mantilla. 2003. pp. 211-212
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Joshi, A, Vresilovic, E, Marcolongo, M, Lowman, A & Karduna, A 2003, The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit: An experimental study. in S Reisman, R Foulds & B Mantilla (eds), Bioengineering, Proceedings of the Northeast Conference. pp. 211-212, Proceedings of the IEEE 29th Annual Northeast Bioengineering Conference, Newark, NJ, United States, 3/22/03.

The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit : An experimental study. / Joshi, Abhijeet; Vresilovic, Edward; Marcolongo, Michele; Lowman, Anthony; Karduna, Andrew.

Bioengineering, Proceedings of the Northeast Conference. ed. / S. Reisman; R. Foulds; B. Mantilla. 2003. p. 211-212.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Joshi A, Vresilovic E, Marcolongo M, Lowman A, Karduna A. The effect of hydrogel nucleus implant on the mechanical behavior of the lumbar functional spinal unit: An experimental study. In Reisman S, Foulds R, Mantilla B, editors, Bioengineering, Proceedings of the Northeast Conference. 2003. p. 211-212