The Effect of Hypoxia and 2,4 Dinitrophenol on Human Placental Glycogen Metabolism

Laurence M. Demers, Steven G. Gabbe, Claude A. Villee, Roy O. Greep

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of 2,4 dinitrophenol and severe hypoxia (1% oxygen) on human placental glycogen metabolism were studied in immature and term human placental villi isolated in an organ culture system. It was observed that both treatments evoked similar changes in human placental glycogen turnover in terms of an acute dependent to independent form synthetase enzyme shift, an activation of the glycogen phosphorylase enzyme system, and a rapid breakdown in placental glycogen. These enzyme changes are consistent with an alteration in intracellular ATP, a known effect of these treatments, and suggest that human placental glycogen may be important to the metabolic energy balance of placental tissue during the course of gestation.

Original languageEnglish (US)
Pages (from-to)724-728
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume140
Issue number2
DOIs
StatePublished - Jun 1972

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2,4-Dinitrophenol
Glycogen
Metabolism
Enzymes
Glycogen Phosphorylase
Chorionic Villi
Enzyme Activation
Organ Culture Techniques
Ligases
Energy balance
Adenosine Triphosphate
Chemical activation
Tissue
Oxygen
Pregnancy
Hypoxia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Demers, Laurence M. ; Gabbe, Steven G. ; Villee, Claude A. ; Greep, Roy O. / The Effect of Hypoxia and 2,4 Dinitrophenol on Human Placental Glycogen Metabolism. In: Proceedings of the Society for Experimental Biology and Medicine. 1972 ; Vol. 140, No. 2. pp. 724-728.
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The Effect of Hypoxia and 2,4 Dinitrophenol on Human Placental Glycogen Metabolism. / Demers, Laurence M.; Gabbe, Steven G.; Villee, Claude A.; Greep, Roy O.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 140, No. 2, 06.1972, p. 724-728.

Research output: Contribution to journalArticle

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