The effect of ketanserin, a specific serotonin antagonist, on burn shock hemodynamic parameters in a porcine burn model

C. James Holliman, Thomas R. Meuleman, Kenneth R. Larsen, J. David Port, Ted H. Stanley, Nathan L. Pace, Glenn D. Warden

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A number of vasoactive substances, including serotonin, have been implicated in the pathophysiology of burn shock. Ketanserin, a specific serotonin antagonist, was investigated in a porcine burn shock model. Fifteen swine were given a mean 44% total body surface area full-thickness scald burn and received fluid resuscitation with Ringer’s lactate for 24 hours postburn. The swine were divided into three groups: Group I (control group) received no ketanserin; Group II received ketanserin as a single intramuscular dose preburn and continuously via intravenous drip postburn; and Group III received ketanserin continuously via intravenous drip postburn only. The ketanserin-treated groups demonstrated improved cardiac index, decreased pulmonary artery pressures, and smaller arteriovenous oxygen content differences compared to the control group in the early postburn period. Ketanserin should be investigated further as a possible adjunctive therapeutic agent during burn shock resuscitation.

Original languageEnglish (US)
Pages (from-to)867-871
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume23
Issue number10
DOIs
StatePublished - Oct 1983

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'The effect of ketanserin, a specific serotonin antagonist, on burn shock hemodynamic parameters in a porcine burn model'. Together they form a unique fingerprint.

Cite this