The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys

HOWARD E. KULIN, Laurence Demers, ALAN D. ROGOL, JOHANNES D. VELDHUIS

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalJournal of Andrology
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1987

Fingerprint

Opiate Alkaloids
Naltrexone
Gonadotropins
Bone and Bones
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

Cite this

KULIN, HOWARD. E., Demers, L., ROGOL, ALAN. D., & VELDHUIS, JOHANNES. D. (1987). The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys. Journal of Andrology, 8(6), 374-377. https://doi.org/10.1002/j.1939-4640.1987.tb00980.x
KULIN, HOWARD E. ; Demers, Laurence ; ROGOL, ALAN D. ; VELDHUIS, JOHANNES D. / The Effect of Long‐Term : Opiate Antagonist Administration to Pubertal Boys. In: Journal of Andrology. 1987 ; Vol. 8, No. 6. pp. 374-377.
@article{fbf00ad833d24950bbc7efcaeb291f99,
title = "The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys",
abstract = "To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology",
author = "KULIN, {HOWARD E.} and Laurence Demers and ROGOL, {ALAN D.} and VELDHUIS, {JOHANNES D.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1002/j.1939-4640.1987.tb00980.x",
language = "English (US)",
volume = "8",
pages = "374--377",
journal = "Journal of Andrology",
issn = "0196-3635",
publisher = "American Society of Andrology Inc.",
number = "6",

}

KULIN, HOWARDE, Demers, L, ROGOL, ALAND & VELDHUIS, JOHANNESD 1987, 'The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys', Journal of Andrology, vol. 8, no. 6, pp. 374-377. https://doi.org/10.1002/j.1939-4640.1987.tb00980.x

The Effect of Long‐Term : Opiate Antagonist Administration to Pubertal Boys. / KULIN, HOWARD E.; Demers, Laurence; ROGOL, ALAN D.; VELDHUIS, JOHANNES D.

In: Journal of Andrology, Vol. 8, No. 6, 01.01.1987, p. 374-377.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Effect of Long‐Term

T2 - Opiate Antagonist Administration to Pubertal Boys

AU - KULIN, HOWARD E.

AU - Demers, Laurence

AU - ROGOL, ALAN D.

AU - VELDHUIS, JOHANNES D.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology

AB - To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology

UR - http://www.scopus.com/inward/record.url?scp=0023489345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023489345&partnerID=8YFLogxK

U2 - 10.1002/j.1939-4640.1987.tb00980.x

DO - 10.1002/j.1939-4640.1987.tb00980.x

M3 - Article

C2 - 3123447

AN - SCOPUS:0023489345

VL - 8

SP - 374

EP - 377

JO - Journal of Andrology

JF - Journal of Andrology

SN - 0196-3635

IS - 6

ER -