The Effect of Pressure on Organic Reactions in Fluids—a New Theoretical Perspective

Bo Chen, Roald Hoffmann, Roberto Cammi

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

This Review brings a new perspective to the study of chemical reactions in compressed fluid media. We begin by reviewing the substantial insight gained from more than 50 years of experimental studies on organic reactions in solution under pressure. These led to a proper estimation of the critical roles of volume of activation (Δ V) and reaction volume (ΔV) in understanding pressure effect on rates and equilibria of organic reactions. A recently developed computational method, the XP-PCM (extreme pressure polarizable continuum model) method, capable of carrying out quantum mechanical calculations of reaction pathways of molecules under pressure, is introduced. A case study of the Diels–Alder cycloaddition of cyclopentadiene with ethylene serves, in pedagogical detail, to describe the methodology. We then apply the XP-PCM method to a selection of other pericyclic reactions, including the parent Diels–Alder cycloaddition of butadiene with ethylene, electrocyclic ring-opening of cyclobutene, electrocyclic ring-closing of Z-hexatriene, the [1,5]-H shift in Z-pentadiene, and the Cope rearrangement. These serve as examples of some of the most common combinations of Δ V and ΔV. Interesting phenomena such as a shift in a transition state along a reaction coordinate, a switch of rate-determining step, and the possible turning of a transition state into a stable minimum are revealed by the calculations. A reaction volume profile, the change in the volume of the reacting molecules as the reaction proceeds, emerges as being useful.

Original languageEnglish (US)
Pages (from-to)11126-11142
Number of pages17
JournalAngewandte Chemie - International Edition
Volume56
Issue number37
DOIs
StatePublished - Jan 1 2017

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Cycloaddition
Pulse code modulation
Ethylene
Alkadienes
Cyclopentanes
Molecules
Pressure effects
Computational methods
Butadiene
Chemical reactions
Chemical activation
Switches
Fluids
ethylene
1,3-butadiene

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

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The Effect of Pressure on Organic Reactions in Fluids—a New Theoretical Perspective. / Chen, Bo; Hoffmann, Roald; Cammi, Roberto.

In: Angewandte Chemie - International Edition, Vol. 56, No. 37, 01.01.2017, p. 11126-11142.

Research output: Contribution to journalReview article

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