The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty

E. J. Susman, J. W. Finkelstein, V. M. Chinchilli, J. Schwab, L. S. Liben, M. R. D'Arcangelo, J. Meinke, L. M. Demers, G. Lookingbill, H. E. Kulin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Objective: The objective of this clinical study was to determine the effects of sex steroids on behavior and mood in adolescents with hypogonadism. Study design: The experimental design consisted of a randomized, double-blind, placebo-controlled, crossover trial lasting for 21 months. The study group consisted of 39 boys and 16 girls recruited from a pediatric endocrine clinic for delayed puberty. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks, alternating with placebo, at 3 dose levels approximating early, middle, and late pubertal amounts. The Child Behavior Checklist, Youth Self Report, Differential Emotion Scale, and Daily Mood Diary were administered after each placebo and treatment period to ascertain the effect of sex steroids on self- and parent-reported behavior problems and moods. Results: The data demonstrated only one significant treatment effect, namely, an increase in withdrawn behavior problems during administration of low-dose estrogen in girls. There were no consistent sex differences. Conclusion: These results demonstrate that administered testosterone or estrogen has minimal effects on behavior problems or mood in adolescents.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalJournal of Pediatrics
Volume133
Issue number4
DOIs
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty'. Together they form a unique fingerprint.

Cite this