The effects of α-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimuriumand Shigella flexneri

Wolfram M. Brück, Shannon L. Kelleher, Glenn R. Gibson, Gitte Graverholt, Bo L. Lönnerdal

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Two milk components, α-lactalbumin (α-La) and glycomacropeptide (GMP) may inhibit intestinal infection/intoxification. 3[H] thymidine-labeled enteropathogenic Escherichia coli (EPEC), Salmonella typhimurium (ATCC 6994) or Shigella flexneri (ATCC 9199) were introduced to CaCo-2 cultures and their association with CaCo-2 cells was assessed. Undigested, pepsin-digested and pepsin- and pancreatin-digested α-lactalbumin and glycomacropeptide inhibited association. Thus, milk supplemented with α-lactalbumin and glycomacropeptide might be effective in inhibiting associations of the pathogens EPEC, Salmonella typhimurium, and Shigella flexneri to intestinal cells.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalFEMS Microbiology Letters
Volume259
Issue number1
DOIs
StatePublished - Jun 2006

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

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