The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.

D. Davis, SH Grossman, BB Kitchell, DG Shand, PA Routledge

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

In 63 healthy ambulant subjects 18 to 88 years of age, the plasma protein binding of diazepam (principally bound to albumin) decreased with age. Diazepam binding in plasma correlated positively with plasma albumin concentration which also decreased with age. In contrast, the plasma protein binding of the basic drug, lignocaine (predominantly bound to alpha 1‐acid glycoprotein [AAG]), tended to increase slightly with age. Lignocaine binding in plasma correlated positively with plasma AAG concentration which also increased slightly with age. Smoking did not affect the plasma protein binding of diazepam or lignocaine or the plasma concentrations of albumin, AAG or nonesterified fatty acids. These results suggest that age‐related changes in plasma protein binding of lignocaine and diazepam are determined in part by age‐related changes in the concentrations of the binding proteins in plasma. The ageing process alone causes only small changes in the plasma protein binding of these drugs compared with the effect of disease states, however. 1985 The British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1985

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this