The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

Thomas J. Gould, Paula C. Bickford

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalBrain research
Volume660
Issue number2
DOIs
StatePublished - Oct 17 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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