TY - JOUR
T1 - The effects of Cl-PFESAs exposure on blood lipids – A community-based large population study in Guangzhou
AU - Mi, Xin
AU - Wu, Lu Yin
AU - Liu, Jiao Jiao
AU - Fang, Qiu Ling
AU - Qian, Zhengmin (Min)
AU - Chu, Chu
AU - Li, Qing Qing
AU - Su, Fan
AU - Zhang, Yun Ting
AU - Zhou, Peien
AU - Zeng, Xiao Wen
AU - Yu, Hong Yao
AU - Dong, Pengxin
AU - Zhou, Yang
AU - Ou, Yanqiu
AU - Xiong, Shimin
AU - Shen, Xubo
AU - Feng, Wenru
AU - Zhou, Yuanzhong
AU - Dong, Guang Hui
N1 - Funding Information:
The research was funded by the National Key Research and Development Program of China (No. 2018YFC1004300 ; No. 2018YFC1004302 ), the National Natural Science Foundation of China (No. 82003409 ; No. 82073503 ; No. 81903287 ; No. 81950410633 ), Guangdong Provincial Natural Science Foundation Team Project ( 2018B030312005 ), Fundamental Research Funds for the Central Universities ( 19ykjc01 ), Natural Science Foundation of Guangdong Province (No. 2021A1515012212 ; No. 2021A151011754 ; No. 2021B15150020015 ; No. 2020A1515011131 ; No. 2019A050510017 ; No. 2018B05052007 ; No. 2017A090905042 ), the Science and Technology Program of Guangzhou (No. 201807010032 ; No. 201803010054 ; No. 201903010023 ).
Publisher Copyright:
© 2021
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Numerous epidemiological studies have investigated the lipid interference effects of legacy PFASs, however, no studies on PFAS alternatives and blood lipids have been published. In this study, we explored the association between Cl-PFESAs, a typical PFASs alternative in China, and blood lipid profiles in 1336 Guangzhou community residents using linear and non-linear regression models. The results showed a deleterious effect of Cl-PFESAs and blood lipids: adjusted estimates (β) for TC, TG, LDL-C and HDL-C per natural log unit increase of 6:2 Cl-PFESA were 0.029 (95% CI: 0.020, 0.038), 0.075 (95% CI: 0.049, 0.101), 0.035 (95% CI: 0.021, 0.049) and −0.071 (95% CI: −0.084, −0.058), respectively. The association between Cl-PFESAs and dyslipidemia was also positively significant (P < 0.05). Furthermore, a non-linear relationship was observed in Cl-PFESAs and serum lipid levels using a restricted cubic splines (RCS) model. In summary, our research suggested a negative impact of Cl-PFESAs on blood lipid patterns and a possible non-linear association.
AB - Numerous epidemiological studies have investigated the lipid interference effects of legacy PFASs, however, no studies on PFAS alternatives and blood lipids have been published. In this study, we explored the association between Cl-PFESAs, a typical PFASs alternative in China, and blood lipid profiles in 1336 Guangzhou community residents using linear and non-linear regression models. The results showed a deleterious effect of Cl-PFESAs and blood lipids: adjusted estimates (β) for TC, TG, LDL-C and HDL-C per natural log unit increase of 6:2 Cl-PFESA were 0.029 (95% CI: 0.020, 0.038), 0.075 (95% CI: 0.049, 0.101), 0.035 (95% CI: 0.021, 0.049) and −0.071 (95% CI: −0.084, −0.058), respectively. The association between Cl-PFESAs and dyslipidemia was also positively significant (P < 0.05). Furthermore, a non-linear relationship was observed in Cl-PFESAs and serum lipid levels using a restricted cubic splines (RCS) model. In summary, our research suggested a negative impact of Cl-PFESAs on blood lipid patterns and a possible non-linear association.
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U2 - 10.1016/j.scitotenv.2021.150634
DO - 10.1016/j.scitotenv.2021.150634
M3 - Article
C2 - 34597565
AN - SCOPUS:85116037872
VL - 806
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
M1 - 150634
ER -