The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity

Juraj Sprung, William Castellani, Venkatramana Srinivasan, Solur Udayashankar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

IMPLICATIONS: We present a case of neuromuscular block of unusual duration in a patient with atypical pseudocholinesterase activity who was taking the acetylcholinesterase inhibitor donepezil and who received succinylcholine and neostigmine as a part of her general anesthesia. To determine the possible role of donepezil in the prolonged neuromuscular block encountered in our patient, we studied the in vitro effects of donepezil on pseudocholinesterase.

Original languageEnglish (US)
Pages (from-to)1203-1205
Number of pages3
JournalAnesthesia and analgesia
Volume87
Issue number5
DOIs
StatePublished - Nov 14 1998

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Pseudocholinesterase
Neostigmine
Neuromuscular Blockade
Succinylcholine
Cholinesterase Inhibitors
General Anesthesia
donepezil

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Sprung, Juraj ; Castellani, William ; Srinivasan, Venkatramana ; Udayashankar, Solur. / The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity. In: Anesthesia and analgesia. 1998 ; Vol. 87, No. 5. pp. 1203-1205.
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The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity. / Sprung, Juraj; Castellani, William; Srinivasan, Venkatramana; Udayashankar, Solur.

In: Anesthesia and analgesia, Vol. 87, No. 5, 14.11.1998, p. 1203-1205.

Research output: Contribution to journalArticle

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