The effects of fetal exchange transfusion with a red blood cell substitute

Anthony Ambrose, Robert C. Cefalo, Watson A. Bowes

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Isovolemic exchange transfusion in the fetal lamb in utero was performed with the use of Fluosol-DA (20%), a perfluorochemical erythrocyte substitute. With maternal hyperoxygenation, a physiologic Po2 was maintained in the fetal lambs, although the total fetal oxygen content decreased as the hematocrit dropped. Because of the oxygen-carrying properties of the perfluorochemical emulsion, the fraction of fetal oxygen carried in the dissolved state increased significantly when compared with that in controls that received saline solution.

Original languageEnglish (US)
Pages (from-to)667-674
Number of pages8
JournalAmerican journal of obstetrics and gynecology
Volume154
Issue number3
DOIs
StatePublished - Mar 1986

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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