The effects of insulin on human placental glycogenesis

Laurence M. Demers, Steven G. Gabbe, Claude A. Villee, Roy O. Greep

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The in vitro effects of insulin on human placental glycogen, glycogen synthetase and glycogen phosphorylase have been studied in fresh immature (10–20 weeks) and term human placental villi. Using an organ culture system, insulin supplementation to the culture medium evoked a glycogenic response in placental tissue in terms of an activation of the glycogen synthetase enzyme system (shift from Dependent to Independent form) and increased glycogen synthesis. The stimulation of placental glycogen synthesis by insulin was consistent irrespective of the glucose concentration, suggesting a direct effect at the level of the glycogen metabolizing enzymes. Results are discussed in light of the mechanisms of action of insulin on glycogenesis in pregnancy.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalEndocrinology
Volume91
Issue number1
DOIs
StatePublished - Jul 1972

Fingerprint

Glycogen
Insulin
Glycogen Synthase
Glycogen Phosphorylase
Chorionic Villi
Organ Culture Techniques
Enzymes
Culture Media
Glucose
Pregnancy

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Demers, L. M., Gabbe, S. G., Villee, C. A., & Greep, R. O. (1972). The effects of insulin on human placental glycogenesis. Endocrinology, 91(1), 270-275. https://doi.org/10.1210/endo-91-1-270
Demers, Laurence M. ; Gabbe, Steven G. ; Villee, Claude A. ; Greep, Roy O. / The effects of insulin on human placental glycogenesis. In: Endocrinology. 1972 ; Vol. 91, No. 1. pp. 270-275.
@article{1e8f902dc6554e54b9f5f500b9b7da6d,
title = "The effects of insulin on human placental glycogenesis",
abstract = "The in vitro effects of insulin on human placental glycogen, glycogen synthetase and glycogen phosphorylase have been studied in fresh immature (10–20 weeks) and term human placental villi. Using an organ culture system, insulin supplementation to the culture medium evoked a glycogenic response in placental tissue in terms of an activation of the glycogen synthetase enzyme system (shift from Dependent to Independent form) and increased glycogen synthesis. The stimulation of placental glycogen synthesis by insulin was consistent irrespective of the glucose concentration, suggesting a direct effect at the level of the glycogen metabolizing enzymes. Results are discussed in light of the mechanisms of action of insulin on glycogenesis in pregnancy.",
author = "Demers, {Laurence M.} and Gabbe, {Steven G.} and Villee, {Claude A.} and Greep, {Roy O.}",
year = "1972",
month = "7",
doi = "10.1210/endo-91-1-270",
language = "English (US)",
volume = "91",
pages = "270--275",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "1",

}

Demers, LM, Gabbe, SG, Villee, CA & Greep, RO 1972, 'The effects of insulin on human placental glycogenesis', Endocrinology, vol. 91, no. 1, pp. 270-275. https://doi.org/10.1210/endo-91-1-270

The effects of insulin on human placental glycogenesis. / Demers, Laurence M.; Gabbe, Steven G.; Villee, Claude A.; Greep, Roy O.

In: Endocrinology, Vol. 91, No. 1, 07.1972, p. 270-275.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of insulin on human placental glycogenesis

AU - Demers, Laurence M.

AU - Gabbe, Steven G.

AU - Villee, Claude A.

AU - Greep, Roy O.

PY - 1972/7

Y1 - 1972/7

N2 - The in vitro effects of insulin on human placental glycogen, glycogen synthetase and glycogen phosphorylase have been studied in fresh immature (10–20 weeks) and term human placental villi. Using an organ culture system, insulin supplementation to the culture medium evoked a glycogenic response in placental tissue in terms of an activation of the glycogen synthetase enzyme system (shift from Dependent to Independent form) and increased glycogen synthesis. The stimulation of placental glycogen synthesis by insulin was consistent irrespective of the glucose concentration, suggesting a direct effect at the level of the glycogen metabolizing enzymes. Results are discussed in light of the mechanisms of action of insulin on glycogenesis in pregnancy.

AB - The in vitro effects of insulin on human placental glycogen, glycogen synthetase and glycogen phosphorylase have been studied in fresh immature (10–20 weeks) and term human placental villi. Using an organ culture system, insulin supplementation to the culture medium evoked a glycogenic response in placental tissue in terms of an activation of the glycogen synthetase enzyme system (shift from Dependent to Independent form) and increased glycogen synthesis. The stimulation of placental glycogen synthesis by insulin was consistent irrespective of the glucose concentration, suggesting a direct effect at the level of the glycogen metabolizing enzymes. Results are discussed in light of the mechanisms of action of insulin on glycogenesis in pregnancy.

UR - http://www.scopus.com/inward/record.url?scp=0015370896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015370896&partnerID=8YFLogxK

U2 - 10.1210/endo-91-1-270

DO - 10.1210/endo-91-1-270

M3 - Article

C2 - 5025700

AN - SCOPUS:0015370896

VL - 91

SP - 270

EP - 275

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 1

ER -

Demers LM, Gabbe SG, Villee CA, Greep RO. The effects of insulin on human placental glycogenesis. Endocrinology. 1972 Jul;91(1):270-275. https://doi.org/10.1210/endo-91-1-270