The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery

Lili Xu, Jianjun Shen, Jianliang Sun, Patrick M. McQuillan, Zhiyong Hu

Research output: Contribution to journalArticle

Abstract

Background: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. Materials and Methods: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T 0), immediately before blood transfusion (T 1), and 1 (T 2), 6 (T 3), and 12 hours (T 4) after end of blood transfusion. Results: The Leukocyte Filter group had higher dynamic respiratory system compliance at T 2, oxygenation index at T 2 and T 3, respiratory index and superoxide dismutase at T 2, T 3, and T 4 than those in the Control group (P<0.05). The Leukocyte Filter group had lower white blood cell, polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, IL-6, IL-8, and tumor necrosis factor-α at T 2, T 3, and T 4 than those in the Control group (P<0.05). There were no significant differences in adverse reactions related specifically to blood transfusion or postoperative respiratory complications within 72 hours. Conclusions: Salvaged autologous blood leukocyte filtration can improve ventilation, promote gas exchange and oxygenation, and inhibit lung inflammatory and oxidative stress reactions in elderly patients undergoing lumbar spinal surgery.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2019

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Autologous Blood Transfusions
Oxidative Stress
Leukocytes
Lung
Blood Transfusion
Pulmonary Surfactant-Associated Protein A
Leukocyte Elastase
Methane
Interleukin-8
Leukocyte Count
Aldehydes
Respiratory System
Control Groups
Compliance
Superoxide Dismutase
Blood Proteins
Interleukin-6
Tumor Necrosis Factor-alpha
Ventilation
Anesthesia

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

@article{038d70544e054e4bbc391d452273f74f,
title = "The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery",
abstract = "Background: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. Materials and Methods: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T 0), immediately before blood transfusion (T 1), and 1 (T 2), 6 (T 3), and 12 hours (T 4) after end of blood transfusion. Results: The Leukocyte Filter group had higher dynamic respiratory system compliance at T 2, oxygenation index at T 2 and T 3, respiratory index and superoxide dismutase at T 2, T 3, and T 4 than those in the Control group (P<0.05). The Leukocyte Filter group had lower white blood cell, polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, IL-6, IL-8, and tumor necrosis factor-α at T 2, T 3, and T 4 than those in the Control group (P<0.05). There were no significant differences in adverse reactions related specifically to blood transfusion or postoperative respiratory complications within 72 hours. Conclusions: Salvaged autologous blood leukocyte filtration can improve ventilation, promote gas exchange and oxygenation, and inhibit lung inflammatory and oxidative stress reactions in elderly patients undergoing lumbar spinal surgery.",
author = "Lili Xu and Jianjun Shen and Jianliang Sun and McQuillan, {Patrick M.} and Zhiyong Hu",
year = "2019",
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doi = "10.1097/ANA.0000000000000495",
language = "English (US)",
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pages = "36--42",
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TY - JOUR

T1 - The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery

AU - Xu, Lili

AU - Shen, Jianjun

AU - Sun, Jianliang

AU - McQuillan, Patrick M.

AU - Hu, Zhiyong

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. Materials and Methods: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T 0), immediately before blood transfusion (T 1), and 1 (T 2), 6 (T 3), and 12 hours (T 4) after end of blood transfusion. Results: The Leukocyte Filter group had higher dynamic respiratory system compliance at T 2, oxygenation index at T 2 and T 3, respiratory index and superoxide dismutase at T 2, T 3, and T 4 than those in the Control group (P<0.05). The Leukocyte Filter group had lower white blood cell, polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, IL-6, IL-8, and tumor necrosis factor-α at T 2, T 3, and T 4 than those in the Control group (P<0.05). There were no significant differences in adverse reactions related specifically to blood transfusion or postoperative respiratory complications within 72 hours. Conclusions: Salvaged autologous blood leukocyte filtration can improve ventilation, promote gas exchange and oxygenation, and inhibit lung inflammatory and oxidative stress reactions in elderly patients undergoing lumbar spinal surgery.

AB - Background: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. Materials and Methods: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T 0), immediately before blood transfusion (T 1), and 1 (T 2), 6 (T 3), and 12 hours (T 4) after end of blood transfusion. Results: The Leukocyte Filter group had higher dynamic respiratory system compliance at T 2, oxygenation index at T 2 and T 3, respiratory index and superoxide dismutase at T 2, T 3, and T 4 than those in the Control group (P<0.05). The Leukocyte Filter group had lower white blood cell, polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, IL-6, IL-8, and tumor necrosis factor-α at T 2, T 3, and T 4 than those in the Control group (P<0.05). There were no significant differences in adverse reactions related specifically to blood transfusion or postoperative respiratory complications within 72 hours. Conclusions: Salvaged autologous blood leukocyte filtration can improve ventilation, promote gas exchange and oxygenation, and inhibit lung inflammatory and oxidative stress reactions in elderly patients undergoing lumbar spinal surgery.

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