In order to evaluate the direct effects of morphine sulfate (MS) on vascular smooth muscle (VSM), a helical strip preparation of canine cutaneous VSM was prepared from vessels of approximately 150 to 250 μ internal diameter. When evaluated at a variety of muscle lengths from 20% to 60% above unstretched length, in the absence and in the presence of norepinephrine (2 to 10x10-4 mg/cc), MS (10-3 to 10-1 mg/cc) failed to produce any noticeable effect. Thus, the well known arterior dilator effect of MS is not a direct effect of the drug on VSM and it is not secondary to blockade of vascular α adrenergic receptors.
|Original language||English (US)|
|Number of pages||4|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Oct 11 1977|
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)