The effects of morphine on isolated cutaneous canine vascular smooth muscle

S. F. Flaim, L. A. Vismara, Robert Zelis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In order to evaluate the direct effects of morphine sulfate (MS) on vascular smooth muscle (VSM), a helical strip preparation of canine cutaneous VSM was prepared from vessels of approximately 150 to 250 μ internal diameter. When evaluated at a variety of muscle lengths from 20% to 60% above unstretched length, in the absence and in the presence of norepinephrine (2 to 10x10-4 mg/cc), MS (10-3 to 10-1 mg/cc) failed to produce any noticeable effect. Thus, the well known arterior dilator effect of MS is not a direct effect of the drug on VSM and it is not secondary to blockade of vascular α adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
StatePublished - Oct 11 1977

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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