The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

Melvin Billingsley, Robert K. Kubena

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Interactions between naloxone and the benzodiazepine, chlordiazepoxide (CDP), were investigated in rats in a Conditioned Suppression of Drinking Test (CSD), which is a model of experimental conflict behavior. Naloxone reversed the anticonflict activity of CDP in this test. Naloxone and picrotoxin were then tested against CDP in rats using the Geller Conflict Test, which is an operant model of conflict behavior. Both naloxone and picrotoxin antagonized the anticonflict effects of CDP. Naloxone and picrotoxin were also tested for their abilities to reverse CDP-induced loss of righting reflexes in mice. Both naloxone and picrotoxin antagonized the loss of righting reflexes induced by CDP. Naloxone had no effect on the loss of righting reflexes induced by barbiturates or meprobamate. These results suggest that naloxone may be useful in the management of benzodiazepine overdoses.

Original languageEnglish (US)
Pages (from-to)897-906
Number of pages10
JournalLife Sciences
Volume22
Issue number10
DOIs
StatePublished - Jan 1 1978

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Picrotoxin
Naloxone
Hypnotics and Sedatives
Benzodiazepines
Chlordiazepoxide
Righting Reflex
Rats
Meprobamate
Barbiturates
Aptitude
Drinking
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Billingsley, Melvin ; Kubena, Robert K. / The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines. In: Life Sciences. 1978 ; Vol. 22, No. 10. pp. 897-906.
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The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines. / Billingsley, Melvin; Kubena, Robert K.

In: Life Sciences, Vol. 22, No. 10, 01.01.1978, p. 897-906.

Research output: Contribution to journalArticle

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