The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

Melvin Billingsley, Robert K. Kubena

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Interactions between naloxone and the benzodiazepine, chlordiazepoxide (CDP), were investigated in rats in a Conditioned Suppression of Drinking Test (CSD), which is a model of experimental conflict behavior. Naloxone reversed the anticonflict activity of CDP in this test. Naloxone and picrotoxin were then tested against CDP in rats using the Geller Conflict Test, which is an operant model of conflict behavior. Both naloxone and picrotoxin antagonized the anticonflict effects of CDP. Naloxone and picrotoxin were also tested for their abilities to reverse CDP-induced loss of righting reflexes in mice. Both naloxone and picrotoxin antagonized the loss of righting reflexes induced by CDP. Naloxone had no effect on the loss of righting reflexes induced by barbiturates or meprobamate. These results suggest that naloxone may be useful in the management of benzodiazepine overdoses.

Original languageEnglish (US)
Pages (from-to)897-906
Number of pages10
JournalLife Sciences
Volume22
Issue number10
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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