The effects of social isolation on wound healing mechanisms in female mice

Leah M. Pyter, Linglan Yang, José M. da Rocha, Christopher Gerald Engeland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Various stressors impair wound healing in humans and rodents. For example, social isolation delays wound closure in rodents, but the healing mechanisms that underlie this delay have yet to be identified. Here, the effects of three weeks of social isolation on hypothalamic-pituitary-adrenal axis responses and healing factors involved in the inflammatory and proliferative phases of wound healing were assessed in adult female hairless mice. Social isolation reduced basal circulating corticosterone concentrations and increased body and thymus weights compared with group-housed controls. Isolation impaired dermal wound closure by up to 30% and reduced initial total wound bacterial load relative to controls. Inflammatory gene expression in the wounds was not affected by the observed differences in wound bacterial load. However, isolation reduced wound gene expression of keratinocyte growth factor and vascular endothelial growth factor, which are involved in keratinocyte proliferation/migration and angiogenesis during the proliferative phase of healing. These data indicate that social isolation induces healing impairments that may be attributed to reductions in growth factors necessary for proper skin cell proliferation and blood vessel growth during healing. This healing impairment occurred in the absence of both high wound bacterial load and elevated circulating glucocorticoids, which have previously been hypothesized to be required for stress-impaired healing in mice.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalPhysiology and Behavior
Volume127
DOIs
StatePublished - Mar 29 2014

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Social Isolation
Wound Healing
Wounds and Injuries
Bacterial Load
Rodentia
Fibroblast Growth Factor 7
Hairless Mouse
Gene Expression
Skin
Corticosterone
Keratinocytes
Thymus Gland
Vascular Endothelial Growth Factor A
Glucocorticoids
Blood Vessels
Intercellular Signaling Peptides and Proteins
Body Weight
Cell Proliferation
Control Groups
Growth

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Pyter, Leah M. ; Yang, Linglan ; da Rocha, José M. ; Engeland, Christopher Gerald. / The effects of social isolation on wound healing mechanisms in female mice. In: Physiology and Behavior. 2014 ; Vol. 127. pp. 64-70.
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The effects of social isolation on wound healing mechanisms in female mice. / Pyter, Leah M.; Yang, Linglan; da Rocha, José M.; Engeland, Christopher Gerald.

In: Physiology and Behavior, Vol. 127, 29.03.2014, p. 64-70.

Research output: Contribution to journalArticle

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