The effects of ventricular hypertrophy on the coronary circulation

M. L. Marcus, J. A. Gascho, T. M. Mueller, Ch Eastham, C. B. Wright, D. B. Doty, L. F. Hiratzka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent animal studies suggest that cardiac hypertrophy compromises the coronary circulation. Although flow per gram of ventricle in most animal models of hypertrophy is normal, coronary vasodilator responses to pharmacological or physiological stimuli are mildly impaired. Studies of regional perfusion indicate that the limitation of coronary vasodilator capacity in hypertrophied ventricles primarily affects the endocardium. In contrast to studies in animals, measurements of coronary reactive hyperemia in man suggest that coronary dilator responses are profoundly depressed in patients with severe left ventricular hypertrophy secondary to aortic stenosis. These studies in man demonstrate that alterations in the coronary circulation secondary to cardiac hypertrophy are of sufficient magnitude to contribute to the development of angina and heart failure (secondary to endocardial fibrosis) in patients with aortic stenosis.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalBasic Research in Cardiology
Volume76
Issue number5
DOIs
StatePublished - Sep 1 1981

Fingerprint

Coronary Circulation
Aortic Valve Stenosis
Cardiomegaly
Vasodilator Agents
Hypertrophy
Endocardium
Hyperemia
Left Ventricular Hypertrophy
Fibrosis
Animal Models
Heart Failure
Perfusion
Pharmacology

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Marcus, M. L., Gascho, J. A., Mueller, T. M., Eastham, C., Wright, C. B., Doty, D. B., & Hiratzka, L. F. (1981). The effects of ventricular hypertrophy on the coronary circulation. Basic Research in Cardiology, 76(5), 575-581. https://doi.org/10.1007/BF01908364
Marcus, M. L. ; Gascho, J. A. ; Mueller, T. M. ; Eastham, Ch ; Wright, C. B. ; Doty, D. B. ; Hiratzka, L. F. / The effects of ventricular hypertrophy on the coronary circulation. In: Basic Research in Cardiology. 1981 ; Vol. 76, No. 5. pp. 575-581.
@article{ef33f40a12204bfe9495e691a713543d,
title = "The effects of ventricular hypertrophy on the coronary circulation",
abstract = "Recent animal studies suggest that cardiac hypertrophy compromises the coronary circulation. Although flow per gram of ventricle in most animal models of hypertrophy is normal, coronary vasodilator responses to pharmacological or physiological stimuli are mildly impaired. Studies of regional perfusion indicate that the limitation of coronary vasodilator capacity in hypertrophied ventricles primarily affects the endocardium. In contrast to studies in animals, measurements of coronary reactive hyperemia in man suggest that coronary dilator responses are profoundly depressed in patients with severe left ventricular hypertrophy secondary to aortic stenosis. These studies in man demonstrate that alterations in the coronary circulation secondary to cardiac hypertrophy are of sufficient magnitude to contribute to the development of angina and heart failure (secondary to endocardial fibrosis) in patients with aortic stenosis.",
author = "Marcus, {M. L.} and Gascho, {J. A.} and Mueller, {T. M.} and Ch Eastham and Wright, {C. B.} and Doty, {D. B.} and Hiratzka, {L. F.}",
year = "1981",
month = "9",
day = "1",
doi = "10.1007/BF01908364",
language = "English (US)",
volume = "76",
pages = "575--581",
journal = "Basic Research in Cardiology",
issn = "0300-8428",
publisher = "D. Steinkopff-Verlag",
number = "5",

}

Marcus, ML, Gascho, JA, Mueller, TM, Eastham, C, Wright, CB, Doty, DB & Hiratzka, LF 1981, 'The effects of ventricular hypertrophy on the coronary circulation', Basic Research in Cardiology, vol. 76, no. 5, pp. 575-581. https://doi.org/10.1007/BF01908364

The effects of ventricular hypertrophy on the coronary circulation. / Marcus, M. L.; Gascho, J. A.; Mueller, T. M.; Eastham, Ch; Wright, C. B.; Doty, D. B.; Hiratzka, L. F.

In: Basic Research in Cardiology, Vol. 76, No. 5, 01.09.1981, p. 575-581.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of ventricular hypertrophy on the coronary circulation

AU - Marcus, M. L.

AU - Gascho, J. A.

AU - Mueller, T. M.

AU - Eastham, Ch

AU - Wright, C. B.

AU - Doty, D. B.

AU - Hiratzka, L. F.

PY - 1981/9/1

Y1 - 1981/9/1

N2 - Recent animal studies suggest that cardiac hypertrophy compromises the coronary circulation. Although flow per gram of ventricle in most animal models of hypertrophy is normal, coronary vasodilator responses to pharmacological or physiological stimuli are mildly impaired. Studies of regional perfusion indicate that the limitation of coronary vasodilator capacity in hypertrophied ventricles primarily affects the endocardium. In contrast to studies in animals, measurements of coronary reactive hyperemia in man suggest that coronary dilator responses are profoundly depressed in patients with severe left ventricular hypertrophy secondary to aortic stenosis. These studies in man demonstrate that alterations in the coronary circulation secondary to cardiac hypertrophy are of sufficient magnitude to contribute to the development of angina and heart failure (secondary to endocardial fibrosis) in patients with aortic stenosis.

AB - Recent animal studies suggest that cardiac hypertrophy compromises the coronary circulation. Although flow per gram of ventricle in most animal models of hypertrophy is normal, coronary vasodilator responses to pharmacological or physiological stimuli are mildly impaired. Studies of regional perfusion indicate that the limitation of coronary vasodilator capacity in hypertrophied ventricles primarily affects the endocardium. In contrast to studies in animals, measurements of coronary reactive hyperemia in man suggest that coronary dilator responses are profoundly depressed in patients with severe left ventricular hypertrophy secondary to aortic stenosis. These studies in man demonstrate that alterations in the coronary circulation secondary to cardiac hypertrophy are of sufficient magnitude to contribute to the development of angina and heart failure (secondary to endocardial fibrosis) in patients with aortic stenosis.

UR - http://www.scopus.com/inward/record.url?scp=0019457698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019457698&partnerID=8YFLogxK

U2 - 10.1007/BF01908364

DO - 10.1007/BF01908364

M3 - Article

C2 - 6458271

AN - SCOPUS:0019457698

VL - 76

SP - 575

EP - 581

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

SN - 0300-8428

IS - 5

ER -