The Electronic Medical Records and Genomics (eMERGE) Network: Past, present, and future

Omri Gottesman, Helena Kuivaniemi, Gerard Tromp, W. Andrew Faucett, Rongling Li, Teri A. Manolio, Saskia C. Sanderson, Joseph Kannry, Randi Zinberg, Melissa A. Basford, Murray Brilliant, David J. Carey, Rex L. Chisholm, Christopher G. Chute, John J. Connolly, David Crosslin, Joshua C. Denny, Carlos J. Gallego, Jonathan L. Haines, Hakon HakonarsonJohn Harley, Gail P. Jarvik, Isaac Kohane, Iftikhar J. Kullo, Eric B. Larson, Catherine McCarty, Marylyn D. Ritchie, Dan M. Roden, Maureen E. Smith, Erwin P. Böttinger, Marc S. Williams

Research output: Contribution to journalReview article

304 Citations (Scopus)

Abstract

The Electronic Medical Records and Genomics Network is a National Human Genome Research Institute-funded consortium engaged in the development of methods and best practices for using the electronic medical record as a tool for genomic research. Now in its sixth year and second funding cycle, and comprising nine research groups and a coordinating center, the network has played a major role in validating the concept that clinical data derived from electronic medical records can be used successfully for genomic research. Current work is advancing knowledge in multiple disciplines at the intersection of genomics and health-care informatics, particularly for electronic phenotyping, genome-wide association studies, genomic medicine implementation, and the ethical and regulatory issues associated with genomics research and returning results to study participants. Here, we describe the evolution, accomplishments, opportunities, and challenges of the network from its inception as a five-group consortium focused on genotype-phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine.

Original languageEnglish (US)
Pages (from-to)761-771
Number of pages11
JournalGenetics in Medicine
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2013

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Electronic Health Records
Genomics
Research
National Human Genome Research Institute (U.S.)
Medicine
Informatics
Genome-Wide Association Study
Genetic Association Studies
Practice Guidelines
Ethics
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

Cite this

Gottesman, O., Kuivaniemi, H., Tromp, G., Faucett, W. A., Li, R., Manolio, T. A., ... Williams, M. S. (2013). The Electronic Medical Records and Genomics (eMERGE) Network: Past, present, and future. Genetics in Medicine, 15(10), 761-771. https://doi.org/10.1038/gim.2013.72
Gottesman, Omri ; Kuivaniemi, Helena ; Tromp, Gerard ; Faucett, W. Andrew ; Li, Rongling ; Manolio, Teri A. ; Sanderson, Saskia C. ; Kannry, Joseph ; Zinberg, Randi ; Basford, Melissa A. ; Brilliant, Murray ; Carey, David J. ; Chisholm, Rex L. ; Chute, Christopher G. ; Connolly, John J. ; Crosslin, David ; Denny, Joshua C. ; Gallego, Carlos J. ; Haines, Jonathan L. ; Hakonarson, Hakon ; Harley, John ; Jarvik, Gail P. ; Kohane, Isaac ; Kullo, Iftikhar J. ; Larson, Eric B. ; McCarty, Catherine ; Ritchie, Marylyn D. ; Roden, Dan M. ; Smith, Maureen E. ; Böttinger, Erwin P. ; Williams, Marc S. / The Electronic Medical Records and Genomics (eMERGE) Network : Past, present, and future. In: Genetics in Medicine. 2013 ; Vol. 15, No. 10. pp. 761-771.
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Gottesman, O, Kuivaniemi, H, Tromp, G, Faucett, WA, Li, R, Manolio, TA, Sanderson, SC, Kannry, J, Zinberg, R, Basford, MA, Brilliant, M, Carey, DJ, Chisholm, RL, Chute, CG, Connolly, JJ, Crosslin, D, Denny, JC, Gallego, CJ, Haines, JL, Hakonarson, H, Harley, J, Jarvik, GP, Kohane, I, Kullo, IJ, Larson, EB, McCarty, C, Ritchie, MD, Roden, DM, Smith, ME, Böttinger, EP & Williams, MS 2013, 'The Electronic Medical Records and Genomics (eMERGE) Network: Past, present, and future', Genetics in Medicine, vol. 15, no. 10, pp. 761-771. https://doi.org/10.1038/gim.2013.72

The Electronic Medical Records and Genomics (eMERGE) Network : Past, present, and future. / Gottesman, Omri; Kuivaniemi, Helena; Tromp, Gerard; Faucett, W. Andrew; Li, Rongling; Manolio, Teri A.; Sanderson, Saskia C.; Kannry, Joseph; Zinberg, Randi; Basford, Melissa A.; Brilliant, Murray; Carey, David J.; Chisholm, Rex L.; Chute, Christopher G.; Connolly, John J.; Crosslin, David; Denny, Joshua C.; Gallego, Carlos J.; Haines, Jonathan L.; Hakonarson, Hakon; Harley, John; Jarvik, Gail P.; Kohane, Isaac; Kullo, Iftikhar J.; Larson, Eric B.; McCarty, Catherine; Ritchie, Marylyn D.; Roden, Dan M.; Smith, Maureen E.; Böttinger, Erwin P.; Williams, Marc S.

In: Genetics in Medicine, Vol. 15, No. 10, 01.10.2013, p. 761-771.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The Electronic Medical Records and Genomics (eMERGE) Network

T2 - Past, present, and future

AU - Gottesman, Omri

AU - Kuivaniemi, Helena

AU - Tromp, Gerard

AU - Faucett, W. Andrew

AU - Li, Rongling

AU - Manolio, Teri A.

AU - Sanderson, Saskia C.

AU - Kannry, Joseph

AU - Zinberg, Randi

AU - Basford, Melissa A.

AU - Brilliant, Murray

AU - Carey, David J.

AU - Chisholm, Rex L.

AU - Chute, Christopher G.

AU - Connolly, John J.

AU - Crosslin, David

AU - Denny, Joshua C.

AU - Gallego, Carlos J.

AU - Haines, Jonathan L.

AU - Hakonarson, Hakon

AU - Harley, John

AU - Jarvik, Gail P.

AU - Kohane, Isaac

AU - Kullo, Iftikhar J.

AU - Larson, Eric B.

AU - McCarty, Catherine

AU - Ritchie, Marylyn D.

AU - Roden, Dan M.

AU - Smith, Maureen E.

AU - Böttinger, Erwin P.

AU - Williams, Marc S.

PY - 2013/10/1

Y1 - 2013/10/1

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AB - The Electronic Medical Records and Genomics Network is a National Human Genome Research Institute-funded consortium engaged in the development of methods and best practices for using the electronic medical record as a tool for genomic research. Now in its sixth year and second funding cycle, and comprising nine research groups and a coordinating center, the network has played a major role in validating the concept that clinical data derived from electronic medical records can be used successfully for genomic research. Current work is advancing knowledge in multiple disciplines at the intersection of genomics and health-care informatics, particularly for electronic phenotyping, genome-wide association studies, genomic medicine implementation, and the ethical and regulatory issues associated with genomics research and returning results to study participants. Here, we describe the evolution, accomplishments, opportunities, and challenges of the network from its inception as a five-group consortium focused on genotype-phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine.

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Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA et al. The Electronic Medical Records and Genomics (eMERGE) Network: Past, present, and future. Genetics in Medicine. 2013 Oct 1;15(10):761-771. https://doi.org/10.1038/gim.2013.72