The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012

John Sebastian Eden, Joanne Hewitt, Kun Lee Lim, Maciej F. Boni, Juan Merif, Gail Greening, Rodney M. Ratcliff, Edward C. Holmes, Mark M. Tanaka, William D. Rawlinson, Peter A. White

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Norovirus is the leading cause of acute gastroenteritis with most infections caused by GII.4 variants. To understand the evolutionary processes that contribute to the emergence of GII.4 variants, we examined the molecular epidemiology of norovirus-associated acute gastroenteritis in Australia and New Zealand from 893 outbreaks between 2009 and 2012. Throughout the study GII.4 New Orleans 2009 was predominant; however, during 2012 it was replaced by an emergent GII.4 variant, Sydney 2012. An evolutionary analysis of capsid gene sequences was performed to determine the origins and selective pressures driving the emergence of these recently circulating GII.4 variants. This revealed that both New Orleans 2009 and Sydney 2012 share a common ancestor with GII.4 Apeldoorn 2007. Furthermore, pre-epidemic ancestral variants of each virus were identified up to two years before their pandemic emergence. Adaptive changes at known blockade epitopes in the viral capsid were also identified that likely contributed to their emergence.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalVirology
Volume450-451
DOIs
StatePublished - Feb 1 2014

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Norovirus
Capsid
Gastroenteritis
Molecular Epidemiology
Pandemics
New Zealand
Disease Outbreaks
Epitopes
Viruses
Infection
Genes

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Eden, J. S., Hewitt, J., Lim, K. L., Boni, M. F., Merif, J., Greening, G., ... White, P. A. (2014). The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology, 450-451, 106-113. https://doi.org/10.1016/j.virol.2013.12.005
Eden, John Sebastian ; Hewitt, Joanne ; Lim, Kun Lee ; Boni, Maciej F. ; Merif, Juan ; Greening, Gail ; Ratcliff, Rodney M. ; Holmes, Edward C. ; Tanaka, Mark M. ; Rawlinson, William D. ; White, Peter A. / The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. In: Virology. 2014 ; Vol. 450-451. pp. 106-113.
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Eden, JS, Hewitt, J, Lim, KL, Boni, MF, Merif, J, Greening, G, Ratcliff, RM, Holmes, EC, Tanaka, MM, Rawlinson, WD & White, PA 2014, 'The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012', Virology, vol. 450-451, pp. 106-113. https://doi.org/10.1016/j.virol.2013.12.005

The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. / Eden, John Sebastian; Hewitt, Joanne; Lim, Kun Lee; Boni, Maciej F.; Merif, Juan; Greening, Gail; Ratcliff, Rodney M.; Holmes, Edward C.; Tanaka, Mark M.; Rawlinson, William D.; White, Peter A.

In: Virology, Vol. 450-451, 01.02.2014, p. 106-113.

Research output: Contribution to journalArticle

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