The enhancement of contextual fear conditioning by ABT-418

Justin W. Kenney, Derek S. Wilkinson, Thomas J. Gould

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity β2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalBehavioural Pharmacology
Issue number3
StatePublished - May 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health


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