The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Ellen H. van den Bogaard, Gary H. Perdew

Research output: Contribution to journalComment/debatepeer-review

Abstract

AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.

Original languageEnglish (US)
Pages (from-to)1385-1388
Number of pages4
JournalJournal of Investigative Dermatology
Volume141
Issue number6
DOIs
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability'. Together they form a unique fingerprint.

Cite this