The epidemiology of renal cell carcinoma. A second look

Joshua E. Muscat, Dietrich Hoffmann, Ernst L. Wynder

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background. From 1973 to 1991, the incidence of kidney cancer in the United States increased by 35.4%. Methods. A multicenter, hospital‐based case—control study was conducted from 1977 to 1993 through an interview of 788 patients with renal cell carcinoma and 779 control subjects. Results. Compared with those who never smoked, the odds ratio (OR) for renal cell carcinoma among current cigarette smokers was 1.4 (95% confidence interval [CI] 1.02‐2.0) for men and 1.1 (95% CI 0.7‐1.6) for women. Among men, there was a rising trend in the odds ratios with increasing pack‐years of smoking (P < 0.01) but not with the number of cigarettes smoked per day. The OR among those currently smoking nonfilter cigarettes exclusively was 2.4 (95% CI 1.2‐4.9) for men and 2.0 (95% CI 0.4‐11.1) for women. No increased risk was observed among current smokers of filter cigarettes. Among men, the OR associated with chewing tobacco was 3.2 (95% CI 1.1‐8.7). Total alcohol consumption was unrelated to the risk of renal cell carcinoma. A joint effect was observed among subjects with a high body mass index who reported a history of hypertension (OR = 1.9, 95% CI 1.01‐3.5) for men and 3.2 (95% CI 1.3‐7.7) for women. Conclusion. High body weight and hypertension were related jointly to renal cell carcinoma. Smoking nonfilter cigarettes and long term cigarette smoking (≧30 years) was a predictor for renal cell carcinoma risk in men. No significant association was found between smoking and renal cell carcinoma in women.

Original languageEnglish (US)
Pages (from-to)2552-2557
Number of pages6
JournalCancer
Volume75
Issue number10
DOIs
StatePublished - May 15 1995

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Renal Cell Carcinoma
Epidemiology
Confidence Intervals
Smoking
Odds Ratio
Tobacco Products
Hypertension
Smokeless Tobacco
Kidney Neoplasms
Alcohol Drinking
Body Mass Index
Body Weight
Interviews
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Muscat, Joshua E. ; Hoffmann, Dietrich ; Wynder, Ernst L. / The epidemiology of renal cell carcinoma. A second look. In: Cancer. 1995 ; Vol. 75, No. 10. pp. 2552-2557.
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The epidemiology of renal cell carcinoma. A second look. / Muscat, Joshua E.; Hoffmann, Dietrich; Wynder, Ernst L.

In: Cancer, Vol. 75, No. 10, 15.05.1995, p. 2552-2557.

Research output: Contribution to journalArticle

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T1 - The epidemiology of renal cell carcinoma. A second look

AU - Muscat, Joshua E.

AU - Hoffmann, Dietrich

AU - Wynder, Ernst L.

PY - 1995/5/15

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N2 - Background. From 1973 to 1991, the incidence of kidney cancer in the United States increased by 35.4%. Methods. A multicenter, hospital‐based case—control study was conducted from 1977 to 1993 through an interview of 788 patients with renal cell carcinoma and 779 control subjects. Results. Compared with those who never smoked, the odds ratio (OR) for renal cell carcinoma among current cigarette smokers was 1.4 (95% confidence interval [CI] 1.02‐2.0) for men and 1.1 (95% CI 0.7‐1.6) for women. Among men, there was a rising trend in the odds ratios with increasing pack‐years of smoking (P < 0.01) but not with the number of cigarettes smoked per day. The OR among those currently smoking nonfilter cigarettes exclusively was 2.4 (95% CI 1.2‐4.9) for men and 2.0 (95% CI 0.4‐11.1) for women. No increased risk was observed among current smokers of filter cigarettes. Among men, the OR associated with chewing tobacco was 3.2 (95% CI 1.1‐8.7). Total alcohol consumption was unrelated to the risk of renal cell carcinoma. A joint effect was observed among subjects with a high body mass index who reported a history of hypertension (OR = 1.9, 95% CI 1.01‐3.5) for men and 3.2 (95% CI 1.3‐7.7) for women. Conclusion. High body weight and hypertension were related jointly to renal cell carcinoma. Smoking nonfilter cigarettes and long term cigarette smoking (≧30 years) was a predictor for renal cell carcinoma risk in men. No significant association was found between smoking and renal cell carcinoma in women.

AB - Background. From 1973 to 1991, the incidence of kidney cancer in the United States increased by 35.4%. Methods. A multicenter, hospital‐based case—control study was conducted from 1977 to 1993 through an interview of 788 patients with renal cell carcinoma and 779 control subjects. Results. Compared with those who never smoked, the odds ratio (OR) for renal cell carcinoma among current cigarette smokers was 1.4 (95% confidence interval [CI] 1.02‐2.0) for men and 1.1 (95% CI 0.7‐1.6) for women. Among men, there was a rising trend in the odds ratios with increasing pack‐years of smoking (P < 0.01) but not with the number of cigarettes smoked per day. The OR among those currently smoking nonfilter cigarettes exclusively was 2.4 (95% CI 1.2‐4.9) for men and 2.0 (95% CI 0.4‐11.1) for women. No increased risk was observed among current smokers of filter cigarettes. Among men, the OR associated with chewing tobacco was 3.2 (95% CI 1.1‐8.7). Total alcohol consumption was unrelated to the risk of renal cell carcinoma. A joint effect was observed among subjects with a high body mass index who reported a history of hypertension (OR = 1.9, 95% CI 1.01‐3.5) for men and 3.2 (95% CI 1.3‐7.7) for women. Conclusion. High body weight and hypertension were related jointly to renal cell carcinoma. Smoking nonfilter cigarettes and long term cigarette smoking (≧30 years) was a predictor for renal cell carcinoma risk in men. No significant association was found between smoking and renal cell carcinoma in women.

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