The epigenetics of gastrointestinal malignancies

Zainul Hasanali, August Stuart, Nelson Shu-Sang Yee, Kamal Sharma, Elliot Epner

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.

Original languageEnglish (US)
Pages (from-to)254-262
Number of pages9
JournalCurrent Colorectal Cancer Reports
Volume8
Issue number4
DOIs
Publication statusPublished - Dec 1 2012

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Oncology
  • Gastroenterology

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