The epigenetics of gastrointestinal malignancies

Zainul Hasanali, August Stuart, Nelson Shu-Sang Yee, Kamal Sharma, Elliot Epner

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.

Original languageEnglish (US)
Pages (from-to)254-262
Number of pages9
JournalCurrent Colorectal Cancer Reports
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2012

Fingerprint

Epigenomics
Neoplasms
Inborn Genetic Diseases
Sequence Deletion
Esophageal Neoplasms
Tumor Suppressor Genes
Pancreatic Neoplasms
Oncogenes
Colorectal Neoplasms
Phenotype

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Oncology
  • Gastroenterology

Cite this

Hasanali, Zainul ; Stuart, August ; Yee, Nelson Shu-Sang ; Sharma, Kamal ; Epner, Elliot. / The epigenetics of gastrointestinal malignancies. In: Current Colorectal Cancer Reports. 2012 ; Vol. 8, No. 4. pp. 254-262.
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The epigenetics of gastrointestinal malignancies. / Hasanali, Zainul; Stuart, August; Yee, Nelson Shu-Sang; Sharma, Kamal; Epner, Elliot.

In: Current Colorectal Cancer Reports, Vol. 8, No. 4, 01.12.2012, p. 254-262.

Research output: Contribution to journalReview article

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