The evolution dynamics of model proteins

Guido Tiana, Nikolay V. Dokholyan, Ricardo A. Broglia, Eugene I. Shakhnovich

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The use of evolution dynamics of model proteins for understanding the similarities between known proteins was discussed. The protein chains were described at a molecular, but simplified level. It was suggested that a number of evolutionary-related quantities, such as the distribution of sequence similarity for structurally similar proteins, are controlled by evolutionary kinetics and do not reflect an equilibrium state. The results for phylogeny show that a subset of the residues of each proteins evolve on a much larger time scale than other residues.

Original languageEnglish (US)
Pages (from-to)2381-2389
Number of pages9
JournalJournal of Chemical Physics
Volume121
Issue number5
DOIs
StatePublished - Aug 1 2004

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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