The evolution of the genetic code took place in an anaerobic environment

Marco Archetti, Massimo Di Giulio

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have compared orthologous proteins from an aerobic organism, Cytophaga hutchinsonii, and from an obligate anaerobe, Bacteroides thetaiotaomicron. This comparison allows us to define the oxyphobic ranks of amino acids, i.e. a scale of the relative sensitivity to oxygen of the amino acid residues. The oxyphobic index (OI), which can be simply obtained from the amino acids' oxyphobic ranks, can be associated to any protein and therefore to the genetic code, if the number of synonymous codons attributed to the amino acids in the code is assumed to be the frequency with which the amino acids appeared in ancestral proteins. Sampling of the OI variable from the proteins of obligate anaerobes and aerobes has established that the OI value of the genetic code is not significantly different from the mean OI value of anaerobe proteins, while it is different from that of aerobe proteins. This observation would seem to suggest that the terminal phases of the evolution of genetic code organization took place in an anaerobic environment. This result is discussed in the framework of hypotheses suggested to explain the timing of the evolutionary appearance of the aerobic metabolism.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalJournal of Theoretical Biology
Volume245
Issue number1
DOIs
StatePublished - Mar 7 2007

Fingerprint

Genetic Code
genetic code
Amino Acids
Amino acids
Proteins
Protein
anaerobes
amino acids
aerobes
proteins
Cytophaga hutchinsonii
Bacteroides thetaiotaomicron
Cytophaga
Metabolism
codons
Codon
Oxygen
Timing
Sampling
oxygen

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

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The evolution of the genetic code took place in an anaerobic environment. / Archetti, Marco; Di Giulio, Massimo.

In: Journal of Theoretical Biology, Vol. 245, No. 1, 07.03.2007, p. 169-174.

Research output: Contribution to journalArticle

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