The evolutionary ecology of host-specificity: Experimental studies with Strongyloides ratti

A. W. Gemmill, M. E. Viney, A. F. Read

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Factors constraining the evolution of host-specificity were investigated using a gastrointestinal parasitic nematode, Strongyloides ratti. S. ratti is a natural parasite of rats which can also reproduce, with decreased success, in laboratory mice. Observed host-specificity arose from lower establishment, reduced per capita fecundity and more rapid expulsion of parasites from mice relative to rats. Variation in the efficacy of thymus-dependent immunity between host species (rats and mice) was insufficient to explain the majority of the observed differences in parasite establishment and reproductive success. The role of natural selection in determining host-specificity was addressed using experimental selection followed by reciprocal fitness assays in both host species. Experimental selection failed to modify the host-specificity of S. ratti to any measurable degree, suggesting either a lack of genetic variation for this trait or the involvement of as yet unidentified factors underlying the differences in S. ratti fitness in rats and mice respectively. These results are discussed in relation to competing theoretical models of ecological specialization, host immunology and previous attempts to experimentally alter the host-specificity of parasitic nematodes.

Original languageEnglish (US)
Pages (from-to)429-437
Number of pages9
JournalParasitology
Volume120
Issue number4
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'The evolutionary ecology of host-specificity: Experimental studies with Strongyloides ratti'. Together they form a unique fingerprint.

Cite this