Abstract
The exercise pressor reflex contributes to increases in cardiovascular and ventilatory function during exercise. These reflexive increases are caused by both mechanical stimulation and metabolic stimulation of group III and IV afferents with endings in contracting skeletal muscle. Patients with peripheral artery disease (PAD) have an augmented exercise pressor reflex. Recently, an animal model of PAD was established which allows further investigation of possible mechanisms involved in this augmented reflex. Earlier studies have identified ASIC3 channels, bradykinin receptors, P2X receptors, endoperoxide receptors, and thromboxane receptors as playing a role in evoking the exercise pressor reflex in healthy rats. This review focuses on recent studies using a rat model of PAD in order to determine possible mechanisms contributing to the exaggerated exercise pressor reflex seen in patients with this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-73 |
| Number of pages | 5 |
| Journal | Autonomic Neuroscience: Basic and Clinical |
| Volume | 188 |
| DOIs | |
| State | Published - Mar 1 2015 |
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All Science Journal Classification (ASJC) codes
- Endocrine and Autonomic Systems
- Clinical Neurology
- Cellular and Molecular Neuroscience
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The exercise pressor reflex and peripheral artery disease. / Stone, Audrey J.; Kaufman, Marc P.
In: Autonomic Neuroscience: Basic and Clinical, Vol. 188, 01.03.2015, p. 69-73.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The exercise pressor reflex and peripheral artery disease
AU - Stone, Audrey J.
AU - Kaufman, Marc P.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - The exercise pressor reflex contributes to increases in cardiovascular and ventilatory function during exercise. These reflexive increases are caused by both mechanical stimulation and metabolic stimulation of group III and IV afferents with endings in contracting skeletal muscle. Patients with peripheral artery disease (PAD) have an augmented exercise pressor reflex. Recently, an animal model of PAD was established which allows further investigation of possible mechanisms involved in this augmented reflex. Earlier studies have identified ASIC3 channels, bradykinin receptors, P2X receptors, endoperoxide receptors, and thromboxane receptors as playing a role in evoking the exercise pressor reflex in healthy rats. This review focuses on recent studies using a rat model of PAD in order to determine possible mechanisms contributing to the exaggerated exercise pressor reflex seen in patients with this disease.
AB - The exercise pressor reflex contributes to increases in cardiovascular and ventilatory function during exercise. These reflexive increases are caused by both mechanical stimulation and metabolic stimulation of group III and IV afferents with endings in contracting skeletal muscle. Patients with peripheral artery disease (PAD) have an augmented exercise pressor reflex. Recently, an animal model of PAD was established which allows further investigation of possible mechanisms involved in this augmented reflex. Earlier studies have identified ASIC3 channels, bradykinin receptors, P2X receptors, endoperoxide receptors, and thromboxane receptors as playing a role in evoking the exercise pressor reflex in healthy rats. This review focuses on recent studies using a rat model of PAD in order to determine possible mechanisms contributing to the exaggerated exercise pressor reflex seen in patients with this disease.
UR - http://www.scopus.com/inward/record.url?scp=84922902159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922902159&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2014.10.014
DO - 10.1016/j.autneu.2014.10.014
M3 - Review article
C2 - 25458431
AN - SCOPUS:84922902159
VL - 188
SP - 69
EP - 73
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
SN - 1566-0702
ER -