The facilitative glucose transporter GLUT3

20 Years of distinction

Ian Simpson, Donard Dwyer, Daniela Malide, Kelle H. Moley, Alexander Travis, Susan J. Vannucci

Research output: Contribution to journalReview article

204 Citations (Scopus)

Abstract

Glucose metabolism is vital to most mammalian cells, and the passage of glucose across cell membranes is facilitated by a family of integral membrane transporter proteins, the GLUTs. There are currently 14 members of the SLC2 family of GLUTs, several of which have been the focus of this series of reviews. The subject of the present review is GLUT3, which, as implied by its name, was the third glucose transporter to be cloned (Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI. J Biol Chem 263: 15245-15248, 1988) and was originally designated as the neuronal GLUT. The overriding question that drove the early work on GLUT3 was why would neurons need a separate glucose transporter isoform? What is it about GLUT3 that specifically suits the needs of the highly metabolic and oxidative neuron with its high glucose demand? More recently, GLUT3 has been studied in other cell types with quite specific requirements for glucose, including sperm, preimplantation embryos, circulating white blood cells, and an array of carcinoma cell lines. The last are sufficiently varied and numerous to warrant a review of their own and will not be discussed here. However, for each of these cases, the same questions apply. Thus, the objective of this review is to discuss the properties and tissue and cellular localization of GLUT3 as well as the features of expression, function, and regulation that distinguish it from the rest of its family and make it uniquely suited as the mediator of glucose delivery to these specific cells.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume295
Issue number2
DOIs
StatePublished - Aug 1 2008

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Facilitative Glucose Transport Proteins
Glucose
Neurons
Membrane Transport Proteins
Blastocyst
Names
Spermatozoa
Protein Isoforms
Membrane Proteins
Leukocytes
Cell Membrane
Carcinoma
Cell Line

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Simpson, Ian ; Dwyer, Donard ; Malide, Daniela ; Moley, Kelle H. ; Travis, Alexander ; Vannucci, Susan J. / The facilitative glucose transporter GLUT3 : 20 Years of distinction. In: American Journal of Physiology - Endocrinology and Metabolism. 2008 ; Vol. 295, No. 2.
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The facilitative glucose transporter GLUT3 : 20 Years of distinction. / Simpson, Ian; Dwyer, Donard; Malide, Daniela; Moley, Kelle H.; Travis, Alexander; Vannucci, Susan J.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 295, No. 2, 01.08.2008.

Research output: Contribution to journalReview article

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AU - Dwyer, Donard

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AU - Travis, Alexander

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