@article{6eaa5a9a0504483ab6b9c0bc037377db,
title = "The feasibility of an in-scanner smoking lapse paradigm to examine the neural correlates of lapses",
abstract = "Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a novel adaption of a well-validated behavioral paradigm. We use data from 17 daily smokers (five females) after 12 h of smoking abstinence. Participants completed up to 10 sequential 5-min functional magnetic resonance imaging (fMRI) runs, within a single scanning session. After each run, participants decided whether to stay in the scanner in order to earn additional money or to terminate the session in order to smoke a cigarette (i.e., lapse) and forego additional monetary reward. Cox regression results indicate that decreased segregation of the default mode system from the frontoparietal system undermines the ability to resist smoking. This study demonstrates the feasibility of modifying an established behavioral model of smoking lapse behavior for use in the neuro imaging environment, and it provides initial evidence that this approach yields valuable information regarding fine-grained, time-varying changes in patterns of neural activity in the moments leading up to a decision to smoke. Specifically, results lend support to the hypothesis that the time-varying interplay between large-scale functional brain systems associated with cognitive control is implicated in smoking lapse behavior.",
author = "Lydon-Staley, {David M.} and MacLean, {R. Ross} and Falk, {Emily B.} and Bassett, {Danielle S.} and Wilson, {Stephen J.}",
note = "Funding Information: Army Research Office, Grant/Award Numbers: W911NF‐18‐1‐0244, DCIST‐W911NF‐17‐2‐0181 and Grafton‐W911NF‐16‐1‐0474, Bassett‐W911NF‐14‐1‐0679; National Institute on Drug Abuse, Grant/Award Numbers: K01DA047417, R21DA045853 and R01DA041438; National Science Foundation, Grant/Award Numbers: BCS‐1631550, NSF PHY‐1554488, BCS‐1430087 and BCS‐1441502; National Institute of Neurological Disorders and Stroke, Grant/Award Number: (R01 NS099348; National Institute of Child Health and Human Development, Grant/Award Number: 1R01HD086888‐01; National Institute of Mental Health, Grant/Award Numbers: R21‐M MH‐106799, R01‐MH107235, R01‐MH112847 and 2‐R01‐DC‐009209‐11; Office of Naval Research; Army Research Laboratory, Grant/Award Number: W911NF‐10‐2‐0022; Paul Allen Foundation; ISI Foundation; Alfred P. Sloan Foundation; John D. and Catherine T. MacArthur Foundation Funding information Funding Information: S.J.W. acknowledges support from the National Institute on Drug Abuse (R01DA041438 and R21DA045853). D.S.B. and D.M.L. acknowledge support from the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the ISI Foundation, the Paul Allen Foundation, the Army Research Laboratory (W911NF‐10‐2‐0022), the Army Research Office (Bassett‐W911NF‐14‐1‐0679, Grafton‐W911NF‐16‐1‐0474, DCIST‐W911NF‐17‐2‐0181), the Office of Naval Research, the National Institute of Mental Health (2‐R01‐DC‐009209‐11, R01‐MH112847, R01‐MH107235, R21‐M MH‐106799), the National Institute of Child Health and Human Development (1R01HD086888‐01), National Institute of Neurological Disorders and Stroke (R01 NS099348), and the National Science Foundation (BCS‐1441502, BCS‐1430087, NSF PHY‐1554488, and BCS‐1631550). D.M.L. acknowledges support from the National Institute on Drug Abuse (K01DA047417). D.M.L, D.S.B, and E.B.F acknowledge support from the Army Research Office (W911NF‐18‐1‐0244). The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. Publisher Copyright: {\textcopyright} 2021 Society for the Study of Addiction Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
doi = "10.1111/adb.13001",
language = "English (US)",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
}