The fibrinolytic system in experimental prostate tumor

H. Al-Mondhiry, J. Drago, M. J. Bartholomew

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hyperfibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalThrombosis and Haemostasis
Volume56
Issue number2
StatePublished - Dec 1 1986

Fingerprint

Prostate
Plasminogen Activators
Transitional Cell Carcinoma
Fibrinolysin
Neoplasms
Fibrinogen
Inbred Strains Rats
Disseminated Intravascular Coagulation
Plasminogen
Fibrinolysis
Hemostatics
Androgens
Prostatic Neoplasms
Urinary Bladder
Neoplasm Metastasis
Carcinoma
Control Groups
Growth

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Al-Mondhiry, H., Drago, J., & Bartholomew, M. J. (1986). The fibrinolytic system in experimental prostate tumor. Thrombosis and Haemostasis, 56(2), 133-136.
Al-Mondhiry, H. ; Drago, J. ; Bartholomew, M. J. / The fibrinolytic system in experimental prostate tumor. In: Thrombosis and Haemostasis. 1986 ; Vol. 56, No. 2. pp. 133-136.
@article{6b1201d9749f480c92cbf8e624af3e42,
title = "The fibrinolytic system in experimental prostate tumor",
abstract = "Hyperfibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.",
author = "H. Al-Mondhiry and J. Drago and Bartholomew, {M. J.}",
year = "1986",
month = "12",
day = "1",
language = "English (US)",
volume = "56",
pages = "133--136",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "2",

}

Al-Mondhiry, H, Drago, J & Bartholomew, MJ 1986, 'The fibrinolytic system in experimental prostate tumor', Thrombosis and Haemostasis, vol. 56, no. 2, pp. 133-136.

The fibrinolytic system in experimental prostate tumor. / Al-Mondhiry, H.; Drago, J.; Bartholomew, M. J.

In: Thrombosis and Haemostasis, Vol. 56, No. 2, 01.12.1986, p. 133-136.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The fibrinolytic system in experimental prostate tumor

AU - Al-Mondhiry, H.

AU - Drago, J.

AU - Bartholomew, M. J.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - Hyperfibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.

AB - Hyperfibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0022979516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022979516&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 133

EP - 136

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 2

ER -

Al-Mondhiry H, Drago J, Bartholomew MJ. The fibrinolytic system in experimental prostate tumor. Thrombosis and Haemostasis. 1986 Dec 1;56(2):133-136.