The fibrinolytic system in experimental prostate tumor

H. Al-Mondhiry, J. Drago, M. J. Bartholomew

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Hyperfibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalThrombosis and Haemostasis
Volume56
Issue number2
DOIs
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • Hematology

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