The formation of an apatite coating on carboxylated polyphosphazenes via a biomimetic process

Justin Lee Brown, Lakshmi S. Nair, Jared Bender, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The biomimetic deposition of an apatite coating on polyphosphazene was investigated. A polyphosphazene having carboxylatophenoxy side groups was synthesized as a candidate polymer with heterogeneous nucleation sites for apatite deposition. Poly[bis(carboxylatophenoxy)phosphazene] (PCPP) was synthesized by a two-step synthetic route involving the synthesis of poly(dichlorophosphazene) (PDP) followed by nucleophilic replacement of the chlorine atoms of PDP with carboxylatophenoxy groups. The surface of the carboxylated polyphosphazene induced the formation of a dense layer of apatite on the surface after incubation in simulated body fluid at 37 °C with an ionic concentration approximately the same as that of human blood plasma. The results suggested an early precipitation of octacalcium phosphate and calcium phosphate intermediates on the surface, both of which are known to promote osteoblast differentiation and proliferation.

Original languageEnglish (US)
Pages (from-to)3692-3695
Number of pages4
JournalMaterials Letters
Volume61
Issue number17
DOIs
StatePublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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