The formation of human populations in South and Central Asia

Vagheesh M. Narasimhan; Nick Patterson; Priya Moorjani; Nadin Rohland; Rebecca Bernardos; Swapan Mallick; Iosif Lazaridis; Nathan Nakatsuka; Iñigo Olalde; Mark Lipson; Alexander M. Kim; Luca M. Olivieri; Alfredo Coppa; Massimo Vidale; James Mallory; Vyacheslav Moiseyev; Egor Kitov; Janet Monge; Nicole Adamski; Neel Alex; Nasreen Broomandkhoshbacht; Francesca Candilio; Kimberly Callan; Olivia Cheronet; Brendan J. Culleton; Matthew Ferry; Daniel Fernandes; Suzanne Freilich; Beatriz Gamarra; Daniel Gaudio; Mateja Hajdinjak; Éadaoin Harney; Thomas K. Harper; Denise Keating; Ann Marie Lawson; Matthew Mah; Kirsten Mandl; Megan Michel; Mario Novak; Jonas Oppenheimer; Niraj Rai; Kendra Sirak; Viviane Slon; Kristin Stewardson; Fatma Zalzala; Zhao Zhang; Gaziz Akhatov; Anatoly N. Bagashev; Alessandra Bagnera; Bauryzhan Baitanayev; Julio Bendezu-Sarmiento; Arman A. Bissembaev; Gian Luca Bonora; Temirlan T. Chargynov; Tatiana Chikisheva; Petr K. Dashkovskiy; Anatoly Derevianko; Miroslav Dobeš; Katerina Douka; Nadezhda Dubova; Meiram N. Duisengali; Dmitry Enshin; Andrey Epimakhov; Alexey V. Fribus; Dorian Fuller; Alexander Goryachev; Andrey Gromov; Sergey P. Grushin; Bryan Hanks; Margaret Judd; Erlan Kazizov; Aleksander Khokhlov; Aleksander P. Krygin; Elena Kupriyanova; Pavel Kuznetsov; Donata Luiselli; Farhod Maksudov; Aslan M. Mamedov; Talgat B. Mamirov; Christopher Meiklejohn; Deborah C. Merrett; Roberto Micheli; Oleg Mochalov; Samariddin Mustafokulov; Ayushi Nayak; Davide Pettener; Richard Potts; Dmitry Razhev; Marina Rykun; Stefania Sarno; Tatyana M. Savenkova; Kulyan Sikhymbaeva; Sergey M. Slepchenko; Oroz A. Soltobaev; Nadezhda Stepanova; Svetlana Svyatko; Kubatbek Tabaldiev; Maria Teschler-Nicola; Alexey A. Tishkin; Vitaly V. Tkachev; Sergey Vasilyev; Petr Velemínský; Dmitriy Voyakin; Antonina Yermolayeva; Muhammad Zahir; Valery S. Zubkov; Alisa Zubova; Vasant S. Shinde; Carles Lalueza-Fox; Matthias Meyer; David Anthony; Nicole Boivin; Kumarasamy Thangaraj; Douglas J. Kennett; Michael Frachetti; Ron Pinhasi; David Reich

doi:10.1126/science.aat7487

The formation of human populations in South and Central Asia

Vagheesh M. Narasimhan, Nick Patterson, Priya Moorjani, Nadin Rohland, Rebecca Bernardos, Swapan Mallick, Iosif Lazaridis, Nathan Nakatsuka, Iñigo Olalde, Mark Lipson, Alexander M. Kim, Luca M. Olivieri, Alfredo Coppa, Massimo Vidale, James Mallory, Vyacheslav Moiseyev, Egor Kitov, Janet Monge, Nicole Adamski, Neel AlexNasreen Broomandkhoshbacht, Francesca Candilio, Kimberly Callan, Olivia Cheronet, Brendan J. Culleton, Matthew Ferry, Daniel Fernandes, Suzanne Freilich, Beatriz Gamarra, Daniel Gaudio, Mateja Hajdinjak, Éadaoin Harney, Thomas K. Harper, Denise Keating, Ann Marie Lawson, Matthew Mah, Kirsten Mandl, Megan Michel, Mario Novak, Jonas Oppenheimer, Niraj Rai, Kendra Sirak, Viviane Slon, Kristin Stewardson, Fatma Zalzala, Zhao Zhang, Gaziz Akhatov, Anatoly N. Bagashev, Alessandra Bagnera, Bauryzhan Baitanayev, Julio Bendezu-Sarmiento, Arman A. Bissembaev, Gian Luca Bonora, Temirlan T. Chargynov, Tatiana Chikisheva, Petr K. Dashkovskiy, Anatoly Derevianko, Miroslav Dobeš, Katerina Douka, Nadezhda Dubova, Meiram N. Duisengali, Dmitry Enshin, Andrey Epimakhov, Alexey V. Fribus, Dorian Fuller, Alexander Goryachev, Andrey Gromov, Sergey P. Grushin, Bryan Hanks, Margaret Judd, Erlan Kazizov, Aleksander Khokhlov, Aleksander P. Krygin, Elena Kupriyanova, Pavel Kuznetsov, Donata Luiselli, Farhod Maksudov, Aslan M. Mamedov, Talgat B. Mamirov, Christopher Meiklejohn, Deborah C. Merrett, Roberto Micheli, Oleg Mochalov, Samariddin Mustafokulov, Ayushi Nayak, Davide Pettener, Richard Potts, Dmitry Razhev, Marina Rykun, Stefania Sarno, Tatyana M. Savenkova, Kulyan Sikhymbaeva, Sergey M. Slepchenko, Oroz A. Soltobaev, Nadezhda Stepanova, Svetlana Svyatko, Kubatbek Tabaldiev, Maria Teschler-Nicola, Alexey A. Tishkin, Vitaly V. Tkachev, Sergey Vasilyev, Petr Velemínský, Dmitriy Voyakin, Antonina Yermolayeva, Muhammad Zahir, Valery S. Zubkov, Alisa Zubova, Vasant S. Shinde, Carles Lalueza-Fox, Matthias Meyer, David Anthony, Nicole Boivin, Kumarasamy Thangaraj, Douglas J. Kennett, Michael Frachetti, Ron Pinhasi, David Reich

Institutes of Energy and the Environment (IEE)

Research output: Contribution to journal › Article

24 Scopus citations

Abstract

By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.

Original language	English (US)
Article number	aat7487
Journal	Science
Volume	365
Issue number	6457
DOIs	https://doi.org/10.1126/science.aat7487
State	Published - Sep 6 2019

All Science Journal Classification (ASJC) codes

General

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10.1126/science.aat7487

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Narasimhan, V. M., Patterson, N., Moorjani, P., Rohland, N., Bernardos, R., Mallick, S., Lazaridis, I., Nakatsuka, N., Olalde, I., Lipson, M., Kim, A. M., Olivieri, L. M., Coppa, A., Vidale, M., Mallory, J., Moiseyev, V., Kitov, E., Monge, J., Adamski, N., ... Reich, D. (2019). The formation of human populations in South and Central Asia. Science, 365(6457), [aat7487]. https://doi.org/10.1126/science.aat7487

Narasimhan, Vagheesh M. ; Patterson, Nick ; Moorjani, Priya ; Rohland, Nadin ; Bernardos, Rebecca ; Mallick, Swapan ; Lazaridis, Iosif ; Nakatsuka, Nathan ; Olalde, Iñigo ; Lipson, Mark ; Kim, Alexander M. ; Olivieri, Luca M. ; Coppa, Alfredo ; Vidale, Massimo ; Mallory, James ; Moiseyev, Vyacheslav ; Kitov, Egor ; Monge, Janet ; Adamski, Nicole ; Alex, Neel ; Broomandkhoshbacht, Nasreen ; Candilio, Francesca ; Callan, Kimberly ; Cheronet, Olivia ; Culleton, Brendan J. ; Ferry, Matthew ; Fernandes, Daniel ; Freilich, Suzanne ; Gamarra, Beatriz ; Gaudio, Daniel ; Hajdinjak, Mateja ; Harney, Éadaoin ; Harper, Thomas K. ; Keating, Denise ; Lawson, Ann Marie ; Mah, Matthew ; Mandl, Kirsten ; Michel, Megan ; Novak, Mario ; Oppenheimer, Jonas ; Rai, Niraj ; Sirak, Kendra ; Slon, Viviane ; Stewardson, Kristin ; Zalzala, Fatma ; Zhang, Zhao ; Akhatov, Gaziz ; Bagashev, Anatoly N. ; Bagnera, Alessandra ; Baitanayev, Bauryzhan ; Bendezu-Sarmiento, Julio ; Bissembaev, Arman A. ; Bonora, Gian Luca ; Chargynov, Temirlan T. ; Chikisheva, Tatiana ; Dashkovskiy, Petr K. ; Derevianko, Anatoly ; Dobeš, Miroslav ; Douka, Katerina ; Dubova, Nadezhda ; Duisengali, Meiram N. ; Enshin, Dmitry ; Epimakhov, Andrey ; Fribus, Alexey V. ; Fuller, Dorian ; Goryachev, Alexander ; Gromov, Andrey ; Grushin, Sergey P. ; Hanks, Bryan ; Judd, Margaret ; Kazizov, Erlan ; Khokhlov, Aleksander ; Krygin, Aleksander P. ; Kupriyanova, Elena ; Kuznetsov, Pavel ; Luiselli, Donata ; Maksudov, Farhod ; Mamedov, Aslan M. ; Mamirov, Talgat B. ; Meiklejohn, Christopher ; Merrett, Deborah C. ; Micheli, Roberto ; Mochalov, Oleg ; Mustafokulov, Samariddin ; Nayak, Ayushi ; Pettener, Davide ; Potts, Richard ; Razhev, Dmitry ; Rykun, Marina ; Sarno, Stefania ; Savenkova, Tatyana M. ; Sikhymbaeva, Kulyan ; Slepchenko, Sergey M. ; Soltobaev, Oroz A. ; Stepanova, Nadezhda ; Svyatko, Svetlana ; Tabaldiev, Kubatbek ; Teschler-Nicola, Maria ; Tishkin, Alexey A. ; Tkachev, Vitaly V. ; Vasilyev, Sergey ; Velemínský, Petr ; Voyakin, Dmitriy ; Yermolayeva, Antonina ; Zahir, Muhammad ; Zubkov, Valery S. ; Zubova, Alisa ; Shinde, Vasant S. ; Lalueza-Fox, Carles ; Meyer, Matthias ; Anthony, David ; Boivin, Nicole ; Thangaraj, Kumarasamy ; Kennett, Douglas J. ; Frachetti, Michael ; Pinhasi, Ron ; Reich, David. / The formation of human populations in South and Central Asia. In: Science. 2019 ; Vol. 365, No. 6457.

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title = "The formation of human populations in South and Central Asia",

abstract = "By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.",

author = "Narasimhan, {Vagheesh M.} and Nick Patterson and Priya Moorjani and Nadin Rohland and Rebecca Bernardos and Swapan Mallick and Iosif Lazaridis and Nathan Nakatsuka and I{\~n}igo Olalde and Mark Lipson and Kim, {Alexander M.} and Olivieri, {Luca M.} and Alfredo Coppa and Massimo Vidale and James Mallory and Vyacheslav Moiseyev and Egor Kitov and Janet Monge and Nicole Adamski and Neel Alex and Nasreen Broomandkhoshbacht and Francesca Candilio and Kimberly Callan and Olivia Cheronet and Culleton, {Brendan J.} and Matthew Ferry and Daniel Fernandes and Suzanne Freilich and Beatriz Gamarra and Daniel Gaudio and Mateja Hajdinjak and {\'E}adaoin Harney and Harper, {Thomas K.} and Denise Keating and Lawson, {Ann Marie} and Matthew Mah and Kirsten Mandl and Megan Michel and Mario Novak and Jonas Oppenheimer and Niraj Rai and Kendra Sirak and Viviane Slon and Kristin Stewardson and Fatma Zalzala and Zhao Zhang and Gaziz Akhatov and Bagashev, {Anatoly N.} and Alessandra Bagnera and Bauryzhan Baitanayev and Julio Bendezu-Sarmiento and Bissembaev, {Arman A.} and Bonora, {Gian Luca} and Chargynov, {Temirlan T.} and Tatiana Chikisheva and Dashkovskiy, {Petr K.} and Anatoly Derevianko and Miroslav Dobe{\v s} and Katerina Douka and Nadezhda Dubova and Duisengali, {Meiram N.} and Dmitry Enshin and Andrey Epimakhov and Fribus, {Alexey V.} and Dorian Fuller and Alexander Goryachev and Andrey Gromov and Grushin, {Sergey P.} and Bryan Hanks and Margaret Judd and Erlan Kazizov and Aleksander Khokhlov and Krygin, {Aleksander P.} and Elena Kupriyanova and Pavel Kuznetsov and Donata Luiselli and Farhod Maksudov and Mamedov, {Aslan M.} and Mamirov, {Talgat B.} and Christopher Meiklejohn and Merrett, {Deborah C.} and Roberto Micheli and Oleg Mochalov and Samariddin Mustafokulov and Ayushi Nayak and Davide Pettener and Richard Potts and Dmitry Razhev and Marina Rykun and Stefania Sarno and Savenkova, {Tatyana M.} and Kulyan Sikhymbaeva and Slepchenko, {Sergey M.} and Soltobaev, {Oroz A.} and Nadezhda Stepanova and Svetlana Svyatko and Kubatbek Tabaldiev and Maria Teschler-Nicola and Tishkin, {Alexey A.} and Tkachev, {Vitaly V.} and Sergey Vasilyev and Petr Velem{\'i}nsk{\'y} and Dmitriy Voyakin and Antonina Yermolayeva and Muhammad Zahir and Zubkov, {Valery S.} and Alisa Zubova and Shinde, {Vasant S.} and Carles Lalueza-Fox and Matthias Meyer and David Anthony and Nicole Boivin and Kumarasamy Thangaraj and Kennett, {Douglas J.} and Michael Frachetti and Ron Pinhasi and David Reich",

year = "2019",

month = sep,

day = "6",

doi = "10.1126/science.aat7487",

language = "English (US)",

volume = "365",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6457",

}

Narasimhan, VM, Patterson, N, Moorjani, P, Rohland, N, Bernardos, R, Mallick, S, Lazaridis, I, Nakatsuka, N, Olalde, I, Lipson, M, Kim, AM, Olivieri, LM, Coppa, A, Vidale, M, Mallory, J, Moiseyev, V, Kitov, E, Monge, J, Adamski, N, Alex, N, Broomandkhoshbacht, N, Candilio, F, Callan, K, Cheronet, O, Culleton, BJ, Ferry, M, Fernandes, D, Freilich, S, Gamarra, B, Gaudio, D, Hajdinjak, M, Harney, É, Harper, TK, Keating, D, Lawson, AM, Mah, M, Mandl, K, Michel, M, Novak, M, Oppenheimer, J, Rai, N, Sirak, K, Slon, V, Stewardson, K, Zalzala, F, Zhang, Z, Akhatov, G, Bagashev, AN, Bagnera, A, Baitanayev, B, Bendezu-Sarmiento, J, Bissembaev, AA, Bonora, GL, Chargynov, TT, Chikisheva, T, Dashkovskiy, PK, Derevianko, A, Dobeš, M, Douka, K, Dubova, N, Duisengali, MN, Enshin, D, Epimakhov, A, Fribus, AV, Fuller, D, Goryachev, A, Gromov, A, Grushin, SP, Hanks, B, Judd, M, Kazizov, E, Khokhlov, A, Krygin, AP, Kupriyanova, E, Kuznetsov, P, Luiselli, D, Maksudov, F, Mamedov, AM, Mamirov, TB, Meiklejohn, C, Merrett, DC, Micheli, R, Mochalov, O, Mustafokulov, S, Nayak, A, Pettener, D, Potts, R, Razhev, D, Rykun, M, Sarno, S, Savenkova, TM, Sikhymbaeva, K, Slepchenko, SM, Soltobaev, OA, Stepanova, N, Svyatko, S, Tabaldiev, K, Teschler-Nicola, M, Tishkin, AA, Tkachev, VV, Vasilyev, S, Velemínský, P, Voyakin, D, Yermolayeva, A, Zahir, M, Zubkov, VS, Zubova, A, Shinde, VS, Lalueza-Fox, C, Meyer, M, Anthony, D, Boivin, N, Thangaraj, K, Kennett, DJ, Frachetti, M, Pinhasi, R & Reich, D 2019, 'The formation of human populations in South and Central Asia', Science, vol. 365, no. 6457, aat7487. https://doi.org/10.1126/science.aat7487

The formation of human populations in South and Central Asia. / Narasimhan, Vagheesh M.; Patterson, Nick; Moorjani, Priya; Rohland, Nadin; Bernardos, Rebecca; Mallick, Swapan; Lazaridis, Iosif; Nakatsuka, Nathan; Olalde, Iñigo; Lipson, Mark; Kim, Alexander M.; Olivieri, Luca M.; Coppa, Alfredo; Vidale, Massimo; Mallory, James; Moiseyev, Vyacheslav; Kitov, Egor; Monge, Janet; Adamski, Nicole; Alex, Neel; Broomandkhoshbacht, Nasreen; Candilio, Francesca; Callan, Kimberly; Cheronet, Olivia; Culleton, Brendan J.; Ferry, Matthew; Fernandes, Daniel; Freilich, Suzanne; Gamarra, Beatriz; Gaudio, Daniel; Hajdinjak, Mateja; Harney, Éadaoin; Harper, Thomas K.; Keating, Denise; Lawson, Ann Marie; Mah, Matthew; Mandl, Kirsten; Michel, Megan; Novak, Mario; Oppenheimer, Jonas; Rai, Niraj; Sirak, Kendra; Slon, Viviane; Stewardson, Kristin; Zalzala, Fatma; Zhang, Zhao; Akhatov, Gaziz; Bagashev, Anatoly N.; Bagnera, Alessandra; Baitanayev, Bauryzhan; Bendezu-Sarmiento, Julio; Bissembaev, Arman A.; Bonora, Gian Luca; Chargynov, Temirlan T.; Chikisheva, Tatiana; Dashkovskiy, Petr K.; Derevianko, Anatoly; Dobeš, Miroslav; Douka, Katerina; Dubova, Nadezhda; Duisengali, Meiram N.; Enshin, Dmitry; Epimakhov, Andrey; Fribus, Alexey V.; Fuller, Dorian; Goryachev, Alexander; Gromov, Andrey; Grushin, Sergey P.; Hanks, Bryan; Judd, Margaret; Kazizov, Erlan; Khokhlov, Aleksander; Krygin, Aleksander P.; Kupriyanova, Elena; Kuznetsov, Pavel; Luiselli, Donata; Maksudov, Farhod; Mamedov, Aslan M.; Mamirov, Talgat B.; Meiklejohn, Christopher; Merrett, Deborah C.; Micheli, Roberto; Mochalov, Oleg; Mustafokulov, Samariddin; Nayak, Ayushi; Pettener, Davide; Potts, Richard; Razhev, Dmitry; Rykun, Marina; Sarno, Stefania; Savenkova, Tatyana M.; Sikhymbaeva, Kulyan; Slepchenko, Sergey M.; Soltobaev, Oroz A.; Stepanova, Nadezhda; Svyatko, Svetlana; Tabaldiev, Kubatbek; Teschler-Nicola, Maria; Tishkin, Alexey A.; Tkachev, Vitaly V.; Vasilyev, Sergey; Velemínský, Petr; Voyakin, Dmitriy; Yermolayeva, Antonina; Zahir, Muhammad; Zubkov, Valery S.; Zubova, Alisa; Shinde, Vasant S.; Lalueza-Fox, Carles; Meyer, Matthias; Anthony, David; Boivin, Nicole; Thangaraj, Kumarasamy; Kennett, Douglas J.; Frachetti, Michael; Pinhasi, Ron; Reich, David.

In: Science, Vol. 365, No. 6457, aat7487, 06.09.2019.

Research output: Contribution to journal › Article

TY - JOUR

T1 - The formation of human populations in South and Central Asia

AU - Narasimhan, Vagheesh M.

AU - Patterson, Nick

AU - Moorjani, Priya

AU - Rohland, Nadin

AU - Bernardos, Rebecca

AU - Mallick, Swapan

AU - Lazaridis, Iosif

AU - Nakatsuka, Nathan

AU - Olalde, Iñigo

AU - Lipson, Mark

AU - Kim, Alexander M.

AU - Olivieri, Luca M.

AU - Coppa, Alfredo

AU - Vidale, Massimo

AU - Mallory, James

AU - Moiseyev, Vyacheslav

AU - Kitov, Egor

AU - Monge, Janet

AU - Adamski, Nicole

AU - Alex, Neel

AU - Broomandkhoshbacht, Nasreen

AU - Candilio, Francesca

AU - Callan, Kimberly

AU - Cheronet, Olivia

AU - Culleton, Brendan J.

AU - Ferry, Matthew

AU - Fernandes, Daniel

AU - Freilich, Suzanne

AU - Gamarra, Beatriz

AU - Gaudio, Daniel

AU - Hajdinjak, Mateja

AU - Harney, Éadaoin

AU - Harper, Thomas K.

AU - Keating, Denise

AU - Lawson, Ann Marie

AU - Mah, Matthew

AU - Mandl, Kirsten

AU - Michel, Megan

AU - Novak, Mario

AU - Oppenheimer, Jonas

AU - Rai, Niraj

AU - Sirak, Kendra

AU - Slon, Viviane

AU - Stewardson, Kristin

AU - Zalzala, Fatma

AU - Zhang, Zhao

AU - Akhatov, Gaziz

AU - Bagashev, Anatoly N.

AU - Bagnera, Alessandra

AU - Baitanayev, Bauryzhan

AU - Bendezu-Sarmiento, Julio

AU - Bissembaev, Arman A.

AU - Bonora, Gian Luca

AU - Chargynov, Temirlan T.

AU - Chikisheva, Tatiana

AU - Dashkovskiy, Petr K.

AU - Derevianko, Anatoly

AU - Dobeš, Miroslav

AU - Douka, Katerina

AU - Dubova, Nadezhda

AU - Duisengali, Meiram N.

AU - Enshin, Dmitry

AU - Epimakhov, Andrey

AU - Fribus, Alexey V.

AU - Fuller, Dorian

AU - Goryachev, Alexander

AU - Gromov, Andrey

AU - Grushin, Sergey P.

AU - Hanks, Bryan

AU - Judd, Margaret

AU - Kazizov, Erlan

AU - Khokhlov, Aleksander

AU - Krygin, Aleksander P.

AU - Kupriyanova, Elena

AU - Kuznetsov, Pavel

AU - Luiselli, Donata

AU - Maksudov, Farhod

AU - Mamedov, Aslan M.

AU - Mamirov, Talgat B.

AU - Meiklejohn, Christopher

AU - Merrett, Deborah C.

AU - Micheli, Roberto

AU - Mochalov, Oleg

AU - Mustafokulov, Samariddin

AU - Nayak, Ayushi

AU - Pettener, Davide

AU - Potts, Richard

AU - Razhev, Dmitry

AU - Rykun, Marina

AU - Sarno, Stefania

AU - Savenkova, Tatyana M.

AU - Sikhymbaeva, Kulyan

AU - Slepchenko, Sergey M.

AU - Soltobaev, Oroz A.

AU - Stepanova, Nadezhda

AU - Svyatko, Svetlana

AU - Tabaldiev, Kubatbek

AU - Teschler-Nicola, Maria

AU - Tishkin, Alexey A.

AU - Tkachev, Vitaly V.

AU - Vasilyev, Sergey

AU - Velemínský, Petr

AU - Voyakin, Dmitriy

AU - Yermolayeva, Antonina

AU - Zahir, Muhammad

AU - Zubkov, Valery S.

AU - Zubova, Alisa

AU - Shinde, Vasant S.

AU - Lalueza-Fox, Carles

AU - Meyer, Matthias

AU - Anthony, David

AU - Boivin, Nicole

AU - Thangaraj, Kumarasamy

AU - Kennett, Douglas J.

AU - Frachetti, Michael

AU - Pinhasi, Ron

AU - Reich, David

PY - 2019/9/6

Y1 - 2019/9/6

N2 - By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.

AB - By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.

UR - http://www.scopus.com/inward/record.url?scp=85071752467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071752467&partnerID=8YFLogxK

U2 - 10.1126/science.aat7487

DO - 10.1126/science.aat7487

M3 - Article

C2 - 31488661

AN - SCOPUS:85071752467

VL - 365

JO - Science

JF - Science

SN - 0036-8075

IS - 6457

M1 - aat7487

ER -