The Globin Family

Arthur M. Lesk, Juliette T.J. Lecomte

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The globins are an ancient family of proteins, appearing in archaea, bacteria, and eukarya. The early determination of the crystal structures of globins, and their amino acid sequences, made possible pioneering investigations of protein evolution-at the level of sequence and of structure, the mechanism of allosteric changes, and the implication of mutations in disease. Many homologs from a wide range of species are now known, with a wide range of functions. This chapter surveys what has been learnt about this family, and what topics continue to be active in current research. It describes the basic globin structure and its variations; the taxonomic distribution of different types of globins; and the variety of known functions, focusing on the mechanism of the allosteric change in mammalian tetrameric hemoglobins and on the effects of mutations with clinical consequences.

Original languageEnglish (US)
Title of host publicationProtein Families
Subtitle of host publicationRelating Protein Sequence, Structure, and Function
Publisherwiley
Pages207-235
Number of pages29
ISBN (Electronic)9781118743089
ISBN (Print)9780470624227
DOIs
StatePublished - Nov 22 2013

All Science Journal Classification (ASJC) codes

  • Computer Science(all)

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