The growth hormone-dependent decrease in hepatic fatty acid synthase mRNA is the result of a decrease in gene transcription

S. S. Donkin, A. D. McNall, B. S. Swencki, J. L. Peters, T. D. Etherton

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The present study was conducted to determine the chronic effects of porcine growth hormone administration on fatty acid synthase (FAS) abundance and gene transcription in rats. Growth hormone treatment increased growth rate approximately 27% (P<0.01). Porcine growth hormone decreased FAS mRNA levels by 55%. The reduction in FAS mRNA was due to a marked decrease in transcription of the FAS gene (decreased by 80%). In contrast, porcine growth hormone did not affect mRNA abundance or transcription rate of another insulin-regulated gene, phosphoenolpyruvate carboxykinase. In summary, our results have established that chronic treatment with growth hormone decreases FAS mRNA by decreasing the transcription rate of the gene. Furthermore, they suggest that the effects of growth hormone are specific and are not mediated by general changes in insulin-responsive gene expression in liver.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalJournal of Molecular Endocrinology
Volume16
Issue number2
DOIs
StatePublished - Apr 1996

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'The growth hormone-dependent decrease in hepatic fatty acid synthase mRNA is the result of a decrease in gene transcription'. Together they form a unique fingerprint.

Cite this