@article{17af797538c4434abb74efa0d4fbd996,
title = "The gut in the brain: the effects of bariatric surgery on alcohol consumption",
abstract = "Obesity represents a major medical and public health problem worldwide. Efforts have been made to develop novel treatments, and among them bariatric surgery is used as an effective treatment to achieve significant, long-term weight loss and alleviate medical problems related to obesity. Alcohol use disorder (AUD) is also a leading cause of morbidity and mortality worldwide. Recent clinical studies have revealed a concern for bariatric surgery patients developing an increased risk for alcohol consumption, and for AUD. A better understanding of the relationship between bariatric surgery and potential later development of AUD is important, given the critical need of identifying patients at high risk for AUD. This paper reviews current clinical and basic science research and discusses potential underlying mechanisms. Special emphasis in this review is given to recent work suggesting that, alterations in alcohol metabolism/pharmacokinetics resulting from bariatric surgery are unlikely to be the primary or at least the only explanation for increased alcohol use and development of AUD, as changes in brain reward processing are also likely to play an important role. Additional studies are needed to clarify the potential role and mechanisms of how bariatric surgery may increase alcohol use and lead to AUD development.",
author = "Blackburn, {Ashley N.} and Andras Hajnal and Lorenzo Leggio",
note = "Funding Information: The authors would like to thank Ms. Karen Smith, National Institutes of Health (NIH) Library for bibliographic assistance. ANB and LL were supported by NIH intramural funding ZIA-AA000218 (Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology; PI: Leggio) jointly supported by the Division of Intramural Clinical and Biological Research of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Intramural Research Program of the National Institute on Drug Abuse (NIDA). AH was supported by NIH grant AA024490, and by a grant from the Pennsylvania Department of Health using Tobacco CURE Funds (SAP # 4100068724). The content of this review is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions. The authors report no biomedical financial interests or potential conflicts of interest related to this research. Funding Information: ANB and LL were supported by NIH intramural funding ZIA-AA000218 (Section on Clinical Psychoneuro-endocrinology and Neuropsychopharmacology; PI: Leggio) jointly supported by the Division of Intramural Clinical and Biological Research of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Intramural Research Program of the National Institute on Drug Abuse (NIDA). AH was supported by NIH grant AA024490, and by a grant from the Pennsylvania Department of Health using Tobacco CURE Funds (SAP # 4100068724). Publisher Copyright: {\textcopyright} 2016 Society for the Study of Addiction",
year = "2017",
month = nov,
doi = "10.1111/adb.12436",
language = "English (US)",
volume = "22",
pages = "1540--1553",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "6",
}