The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions

Scott R. Blechinger, Tyler G. Evans, Ping Tao Tang, John Y. Kuwada, James T. Warren, Patrick H. Krone

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

In the present study, we show that the stress-inducible hsp70 gene in zebrafish is strongly and specifically expressed during normal lens formation from 28 to 38 hours post-fertilization, and is subsequently downregulated by 2 days of age. Only weak constitutive hsp70 mRNA signal was sporadically observed in other embryonic tissues. Similarly, transgenic fish carrying a 1.5kb fragment of the hsp70 promoter linked to eGFP exhibited fluorescence only in the lens. In contrast, both the endogenous hsp70 gene and the transgene were strongly expressed throughout the embryo following heat shock at the same developmental stages.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalMechanisms of Development
Volume112
Issue number1-2
DOIs
StatePublished - Mar 4 2002

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Fingerprint Dive into the research topics of 'The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions'. Together they form a unique fingerprint.

  • Cite this