The high mobility group I-C gene (HMGI-C): Polymorphism and genetic localization

C. S. Ishwad, Mark Shriver, D. M. Lassige, R. E. Ferrell

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Abstract

We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalHuman genetics
Volume99
Issue number1
DOIs
Publication statusPublished - Dec 1 1996

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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