The high mobility group I-C gene (HMGI-C): Polymorphism and genetic localization

C. S. Ishwad, M. D. Shriver, D. M. Lassige, R. E. Ferrell

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalHuman genetics
Volume99
Issue number1
DOIs
StatePublished - Dec 1996

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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