The histocompatibility-2 system in wild mice - XI. Ss and Slp properties of wild-derived H-2 haplotypes

Howard C. Passmore, Janice K. Kubo, Sujay K. Singh, Jan Klein

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, 14 B10.W lines were examined for genetic traits associated with the Ss protein and Slp alloantigen. Three B10.W lines were found to possess low levels of serum Slp alloantigen. Of these three Slp-positive lines, expression of the alloantigen was sex-limited in two lines (B10.LIB55 and B10.STA12) and constitutive, i.e., found in both sexes, in the remaining line (B10.KPB128). Lines which were found to be Slp-negative were also tested for IA-controlled immune response to Slp alloimmunization. The finding that one of these Slp-negative lines produced no detectable anti-Slp indicates that non-responder alleles exist in wild populations. Further, the discovery of an unexpected immune response to Slp in F1 hybrids involving lines B10.LIB55 and B10.STA12 suggests the existence of a variant form of Slp alloantigen in these lines.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalImmunogenetics
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1980

Fingerprint

Histocompatibility
Isoantigens
Haplotypes
Alleles
Serum
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Passmore, Howard C. ; Kubo, Janice K. ; Singh, Sujay K. ; Klein, Jan. / The histocompatibility-2 system in wild mice - XI. Ss and Slp properties of wild-derived H-2 haplotypes. In: Immunogenetics. 1980 ; Vol. 11, No. 1. pp. 397-405.
@article{094d3712e7a245c6b16d74a1655e79cf,
title = "The histocompatibility-2 system in wild mice - XI. Ss and Slp properties of wild-derived H-2 haplotypes",
abstract = "In this study, 14 B10.W lines were examined for genetic traits associated with the Ss protein and Slp alloantigen. Three B10.W lines were found to possess low levels of serum Slp alloantigen. Of these three Slp-positive lines, expression of the alloantigen was sex-limited in two lines (B10.LIB55 and B10.STA12) and constitutive, i.e., found in both sexes, in the remaining line (B10.KPB128). Lines which were found to be Slp-negative were also tested for IA-controlled immune response to Slp alloimmunization. The finding that one of these Slp-negative lines produced no detectable anti-Slp indicates that non-responder alleles exist in wild populations. Further, the discovery of an unexpected immune response to Slp in F1 hybrids involving lines B10.LIB55 and B10.STA12 suggests the existence of a variant form of Slp alloantigen in these lines.",
author = "Passmore, {Howard C.} and Kubo, {Janice K.} and Singh, {Sujay K.} and Jan Klein",
year = "1980",
month = "1",
day = "1",
doi = "10.1007/BF01567806",
language = "English (US)",
volume = "11",
pages = "397--405",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "1",

}

The histocompatibility-2 system in wild mice - XI. Ss and Slp properties of wild-derived H-2 haplotypes. / Passmore, Howard C.; Kubo, Janice K.; Singh, Sujay K.; Klein, Jan.

In: Immunogenetics, Vol. 11, No. 1, 01.01.1980, p. 397-405.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The histocompatibility-2 system in wild mice - XI. Ss and Slp properties of wild-derived H-2 haplotypes

AU - Passmore, Howard C.

AU - Kubo, Janice K.

AU - Singh, Sujay K.

AU - Klein, Jan

PY - 1980/1/1

Y1 - 1980/1/1

N2 - In this study, 14 B10.W lines were examined for genetic traits associated with the Ss protein and Slp alloantigen. Three B10.W lines were found to possess low levels of serum Slp alloantigen. Of these three Slp-positive lines, expression of the alloantigen was sex-limited in two lines (B10.LIB55 and B10.STA12) and constitutive, i.e., found in both sexes, in the remaining line (B10.KPB128). Lines which were found to be Slp-negative were also tested for IA-controlled immune response to Slp alloimmunization. The finding that one of these Slp-negative lines produced no detectable anti-Slp indicates that non-responder alleles exist in wild populations. Further, the discovery of an unexpected immune response to Slp in F1 hybrids involving lines B10.LIB55 and B10.STA12 suggests the existence of a variant form of Slp alloantigen in these lines.

AB - In this study, 14 B10.W lines were examined for genetic traits associated with the Ss protein and Slp alloantigen. Three B10.W lines were found to possess low levels of serum Slp alloantigen. Of these three Slp-positive lines, expression of the alloantigen was sex-limited in two lines (B10.LIB55 and B10.STA12) and constitutive, i.e., found in both sexes, in the remaining line (B10.KPB128). Lines which were found to be Slp-negative were also tested for IA-controlled immune response to Slp alloimmunization. The finding that one of these Slp-negative lines produced no detectable anti-Slp indicates that non-responder alleles exist in wild populations. Further, the discovery of an unexpected immune response to Slp in F1 hybrids involving lines B10.LIB55 and B10.STA12 suggests the existence of a variant form of Slp alloantigen in these lines.

UR - http://www.scopus.com/inward/record.url?scp=0019272590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019272590&partnerID=8YFLogxK

U2 - 10.1007/BF01567806

DO - 10.1007/BF01567806

M3 - Article

C2 - 6776047

AN - SCOPUS:0019272590

VL - 11

SP - 397

EP - 405

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 1

ER -