The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure

Guoli Chen, Xiaoyang Zhou, Anand Pathak, Gerald W. Dorn, Evangelia G. Kranias

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: A human protein phosphatase inhibitor-1 polymorphism, G147D (c.440G>A, p.147G>D), has been previously demonstrated to blunt the contractile responses of cardiomyocytes to β-adrenergic agonists. The present study sought to examine whether the G147D inhibitor-1 polymorphism may be associated with specific clinical characteristics of heart failure carriers. Methods: Clinical information of 963 heart failure patients was analyzed according to race, inhibitor-1 genotype, treatment with β-blockers and mortality patterns. Results: The G147D inhibitor-1 genetic variant was found almost exclusively in black subjects and its frequency was similar between normals and heart failure patients, indicating that it was not a primary risk factor for developing heart failure. Comparison of the major cardiac functional parameters and transplant-free survival patterns between carrier and noncarrier patients did not reveal any significant differences. Furthermore, echocardiographic evaluation showed similar outcomes of β-blocker treatment between G147D carriers and noncarriers. Conclusions: The present findings indicate that the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalCardiology
Volume112
Issue number3
DOIs
StatePublished - Jan 2009

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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