The hydroxylation of biphenyl by Aspergillus toxicarius: Conditions for a bench scale fermentation process

John H. Golbeck, John C. Cox

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fungi of the Aspergillus sp. can hydroxyate biphenyl to 4,4′‐dihydroxybiphenyl, a chemical intermediate used in the plastics industry. The authors studied various batch culture conditions for the production of 4,4′‐dihydroxybiphenyl, by Aspergillus toxicarius, in 25‐mL shake flasks and 2‐L fermenter cultures. Conditions investigated included temperature, aeration, carbon and nitrogen sources, biomass content, and time of substrate addition. Under optimum conditions we observed a rate of 4,4′‐dihydroxybiphenyl production of 15–20 mg/day/g dry wt mycelia. Such a production rate is probably too low to support a commercial process and possible reasons for the low productivity are discussed.

Original languageEnglish (US)
Pages (from-to)434-441
Number of pages8
JournalBiotechnology and bioengineering
Volume26
Issue number5
DOIs
StatePublished - May 1984

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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