The “Ice Age” in Cardiac Surgery: Evolution of the “Siberian” Method of Brain Protection During Deep Hypothermic Perfusionless Circulatory Arrest

Dmitri Guvakov, Dmitri Bezinover, Vladimir V. Lomivorotov, Vadim G. Postnov, Stuart J. Weiss, Albert T. Cheung, Julie Swain, Vladimir N. Lomivorotov

Research output: Contribution to journalArticle


Deep hypothermic perfusionless circulatory arrest was the first practical neuroprotective technique used for open-heart surgery. It was refined at the Novosibirsk Medical Research Center in Siberia and was actively used from the mid-1950s until 2001.This review describes the development of this technique and its contribution to our understanding of the dynamic changes in human physiology during induced hypothermia for circulatory arrest without extracorporeal perfusion. Deep hypothermic perfusionless circulatory arrest was an important stepping stone in the development of modern approaches in neuroprotection and monitoring during cardiac surgery.

Original languageEnglish (US)
Pages (from-to)3366-3374
Number of pages9
JournalJournal of cardiothoracic and vascular anesthesia
Issue number12
Publication statusPublished - Dec 2019


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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