The impact of anemia on child mortality: An updated review

Samuel P. Scott, Lenis P. Chen-Edinboro, Laura E. Caulfield, Laura E. Murray-Kolb

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Iron deficiency anemia and child mortality are public health problems requiring urgent attention. However, the degree to which iron deficiency anemia contributes to child mortality is unknown. Here, we utilized an exhaustive article search and screening process to identify articles containing both anemia and mortality data for children aged 28 days to 12 years. We then estimated the reduction in risk of mortality associated with a 1-g/dL increase in hemoglobin (Hb). Our meta-analysis of nearly 12,000 children from six African countries revealed a combined odds ratio of 0.76 (0.62–0.93), indicating that for each 1-g/dL increase in Hb, the risk of death falls by 24%. The feasibility of a 1-g/dL increase in Hb has been demonstrated via simple iron supplementation strategies. Our finding suggests that ~1.8 million deaths in children aged 28 days to five years could be avoided each year by increasing Hb in these children by 1 g/dL.

Original languageEnglish (US)
Pages (from-to)5915-5932
Number of pages18
JournalNutrients
Volume6
Issue number12
DOIs
StatePublished - Dec 22 2014

Fingerprint

Child Mortality
anemia
Anemia
Hemoglobins
Iron-Deficiency Anemias
hemoglobin
iron deficiency anemia
Risk Reduction Behavior
death
Meta-Analysis
Iron
Public Health
risk reduction
Odds Ratio
meta-analysis
odds ratio
Mortality
public health
iron
screening

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Scott, S. P., Chen-Edinboro, L. P., Caulfield, L. E., & Murray-Kolb, L. E. (2014). The impact of anemia on child mortality: An updated review. Nutrients, 6(12), 5915-5932. https://doi.org/10.3390/nu6125915
Scott, Samuel P. ; Chen-Edinboro, Lenis P. ; Caulfield, Laura E. ; Murray-Kolb, Laura E. / The impact of anemia on child mortality : An updated review. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5915-5932.
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Scott, SP, Chen-Edinboro, LP, Caulfield, LE & Murray-Kolb, LE 2014, 'The impact of anemia on child mortality: An updated review', Nutrients, vol. 6, no. 12, pp. 5915-5932. https://doi.org/10.3390/nu6125915

The impact of anemia on child mortality : An updated review. / Scott, Samuel P.; Chen-Edinboro, Lenis P.; Caulfield, Laura E.; Murray-Kolb, Laura E.

In: Nutrients, Vol. 6, No. 12, 22.12.2014, p. 5915-5932.

Research output: Contribution to journalReview article

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AU - Chen-Edinboro, Lenis P.

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