The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders

Christine Marcelle Heim, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The relative contribution of genetic and environmental factors to the development of the major psychiatric disorders has long been debated. Recently, considerable attention has been given to the observations that adverse experiences early in life predispose individuals to the development of affective and anxiety disorders in adulthood. Corticotropin-releasing factor (CRF) is the central coordinator of the endocrinologic, autonomic, immunologic, and behavioral stress responses. When centrally administered, CRF produces many physiologic and behavioral changes reminiscent of both acute stress and depression. Moreover, CRF has also been implicated in the pathogenesis of a variety of anxiety disorders, mainly through CRF neurocircuits connecting the amygdala and the locus ceruleus. Clinical studies have provided convincing evidence for central CRF hypersecretion in depression, and, to a lesser extent, in some anxiety disorders. Evidence mainly from preclinical studies suggests that stress early in life results in persistent central CRF hyperactivity and increased stress reactivity in adulthood. Thus, genetic disposition coupled with early stress in critical phases of development may result in a phenotype that is neurobiologically vulnerable to stress and may lower an individual's threshold for developing depression and anxiety upon further stress exposure. This pathophysiologic model may provide novel approaches to the prevention and treatment of psychopathology associated with stress early in life.

Original languageEnglish (US)
Title of host publicationDepression
Subtitle of host publicationThe Science of Mental Health
PublisherTaylor and Francis
Pages205-218
Number of pages14
Volume6
ISBN (Electronic)9781315054322
ISBN (Print)9780815337492
StatePublished - Oct 15 2013

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All Science Journal Classification (ASJC) codes

  • Health Professions(all)
  • Medicine(all)

Cite this

Heim, C. M., & Nemeroff, C. B. (2013). The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. In Depression: The Science of Mental Health (Vol. 6, pp. 205-218). Taylor and Francis.