The impact of patient-specific vascular structure on localized cooling in the human heart

Nathan Spangenberg, Thomas Merrill, Jennifer Mitchell, Anilchandra Attaluri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Acute Myocardial Infarction (AMI) is the leading cause of worldwide death and disability, and approximately 720,000 Americans will experience an AMI in 2018. Studies have shown that rapid hypothermia therapy (< 35°C) before reperfusion in patients with AMI can reduce infarct size by 37%. Localized therapeutic hypothermia has proven the potential to cool heart tissue rapidly following AMI, 3°C in 5 minutes. Using digital imaging software and the finite volume method we analyzed temperature distributions in six patient-specific LCX artery models. A mock circulatory loop was used to determine the exiting temperatures of a standard 7 Fr catheter with flow rates ranging from 9.1 ml/min to 88.9 ml/min for input into our model. The said flow rates were fed into our model using 0.45 W and 128.4 W of cooling, respectively. Our work showed typical exit temperatures were between 35.8°C and 36.9°C using a 29.2 ml/min catheter infusion flow rate in all six heart models. Additionally, results of this study indicate that biovariability in patient-specific vascular structures significantly impacts Therapeutic Hypothermia (TH) treatment methods. These results indicate that further research is needed to examine more accurate physiological effects, such as pulsatile flow. Future models will be used to provide insight to guide more efficient TH device designs and operational parameters to optimize patient outcomes following AMI.

Original languageEnglish (US)
Title of host publicationFrontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791841037
DOIs
StatePublished - Jan 1 2019
Event2019 Design of Medical Devices Conference, DMD 2019 - Minneapolis, United States
Duration: Apr 15 2019Apr 18 2019

Publication series

NameFrontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019

Conference

Conference2019 Design of Medical Devices Conference, DMD 2019
CountryUnited States
CityMinneapolis
Period4/15/194/18/19

Fingerprint

Hypothermia
Cooling
Catheters
Flow rate
Pulsatile flow
Finite volume method
Temperature distribution
Tissue
Imaging techniques
Temperature

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Spangenberg, N., Merrill, T., Mitchell, J., & Attaluri, A. (2019). The impact of patient-specific vascular structure on localized cooling in the human heart. In Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019 (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DMD2019-3223
Spangenberg, Nathan ; Merrill, Thomas ; Mitchell, Jennifer ; Attaluri, Anilchandra. / The impact of patient-specific vascular structure on localized cooling in the human heart. Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), 2019. (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).
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abstract = "Acute Myocardial Infarction (AMI) is the leading cause of worldwide death and disability, and approximately 720,000 Americans will experience an AMI in 2018. Studies have shown that rapid hypothermia therapy (< 35°C) before reperfusion in patients with AMI can reduce infarct size by 37{\%}. Localized therapeutic hypothermia has proven the potential to cool heart tissue rapidly following AMI, 3°C in 5 minutes. Using digital imaging software and the finite volume method we analyzed temperature distributions in six patient-specific LCX artery models. A mock circulatory loop was used to determine the exiting temperatures of a standard 7 Fr catheter with flow rates ranging from 9.1 ml/min to 88.9 ml/min for input into our model. The said flow rates were fed into our model using 0.45 W and 128.4 W of cooling, respectively. Our work showed typical exit temperatures were between 35.8°C and 36.9°C using a 29.2 ml/min catheter infusion flow rate in all six heart models. Additionally, results of this study indicate that biovariability in patient-specific vascular structures significantly impacts Therapeutic Hypothermia (TH) treatment methods. These results indicate that further research is needed to examine more accurate physiological effects, such as pulsatile flow. Future models will be used to provide insight to guide more efficient TH device designs and operational parameters to optimize patient outcomes following AMI.",
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Spangenberg, N, Merrill, T, Mitchell, J & Attaluri, A 2019, The impact of patient-specific vascular structure on localized cooling in the human heart. in Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019, American Society of Mechanical Engineers (ASME), 2019 Design of Medical Devices Conference, DMD 2019, Minneapolis, United States, 4/15/19. https://doi.org/10.1115/DMD2019-3223

The impact of patient-specific vascular structure on localized cooling in the human heart. / Spangenberg, Nathan; Merrill, Thomas; Mitchell, Jennifer; Attaluri, Anilchandra.

Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), 2019. (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Acute Myocardial Infarction (AMI) is the leading cause of worldwide death and disability, and approximately 720,000 Americans will experience an AMI in 2018. Studies have shown that rapid hypothermia therapy (< 35°C) before reperfusion in patients with AMI can reduce infarct size by 37%. Localized therapeutic hypothermia has proven the potential to cool heart tissue rapidly following AMI, 3°C in 5 minutes. Using digital imaging software and the finite volume method we analyzed temperature distributions in six patient-specific LCX artery models. A mock circulatory loop was used to determine the exiting temperatures of a standard 7 Fr catheter with flow rates ranging from 9.1 ml/min to 88.9 ml/min for input into our model. The said flow rates were fed into our model using 0.45 W and 128.4 W of cooling, respectively. Our work showed typical exit temperatures were between 35.8°C and 36.9°C using a 29.2 ml/min catheter infusion flow rate in all six heart models. Additionally, results of this study indicate that biovariability in patient-specific vascular structures significantly impacts Therapeutic Hypothermia (TH) treatment methods. These results indicate that further research is needed to examine more accurate physiological effects, such as pulsatile flow. Future models will be used to provide insight to guide more efficient TH device designs and operational parameters to optimize patient outcomes following AMI.

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M3 - Conference contribution

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Spangenberg N, Merrill T, Mitchell J, Attaluri A. The impact of patient-specific vascular structure on localized cooling in the human heart. In Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME). 2019. (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019). https://doi.org/10.1115/DMD2019-3223