The impact of protocol assignment for older adolescents with Hodgkin lymphoma

Richard S. Pieters, Henry Wagner, Stephen Baker, Karen Morano, Kenneth Ulin, Maria Giulia Cicchetti, Maryann Bishop-Jodoin, Thomas J. FitzGerald

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Purpose: Hodgkin lymphoma (HL) treatment has evolved to reduce or avoid radiotherapy (RT) dose and volume and minimize the potential for late effects. Some older adolescents are treated on adult protocols. The purpose of this study is to examine the protocol assignment of older adolescents and its impact on radiation dose to relevant thoracic structures. Materials and Methods: Cooperative group data were reviewed and 12 adolescents were randomly selected from a pediatric HL protocol. Treatment plans were generated per one pediatric and two adult protocols. Dose volume histograms for heart, lung, and breast allowed comparison of radiation dose to these sites across these three protocols. Results: A total of 15.2% of adolescents were treated on adult HL protocols and received significantly higher radiation dosage to heart and lung compared to pediatric HL protocols. Adolescents treated on either pediatric or adult protocols received similar RT dose to breast. Conclusion: Older adolescents treated on adult HL protocols received higher RT dose to thoracic structures except breast. Level of nodal involvement may impact overall RT dose to breast. The impact of varying field design and RT dose on survival, local, and late effects needs further study for this vulnerable age group. Adolescents, young adults, Hodgkin lymphoma, RT, clinical trials.

Original languageEnglish (US)
Article number317
JournalFrontiers in Oncology
Volume4
Issue numberNOV
DOIs
StatePublished - Jan 1 2014

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Hodgkin Disease
Radiotherapy
Breast
Pediatrics
Thorax
Radiation
Radiation Dosage
Lung
Cardiac Volume
Young Adult
Age Groups
Clinical Trials
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Pieters, R. S., Wagner, H., Baker, S., Morano, K., Ulin, K., Cicchetti, M. G., ... FitzGerald, T. J. (2014). The impact of protocol assignment for older adolescents with Hodgkin lymphoma. Frontiers in Oncology, 4(NOV), [317]. https://doi.org/10.3389/fonc.2014.00317
Pieters, Richard S. ; Wagner, Henry ; Baker, Stephen ; Morano, Karen ; Ulin, Kenneth ; Cicchetti, Maria Giulia ; Bishop-Jodoin, Maryann ; FitzGerald, Thomas J. / The impact of protocol assignment for older adolescents with Hodgkin lymphoma. In: Frontiers in Oncology. 2014 ; Vol. 4, No. NOV.
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abstract = "Background and Purpose: Hodgkin lymphoma (HL) treatment has evolved to reduce or avoid radiotherapy (RT) dose and volume and minimize the potential for late effects. Some older adolescents are treated on adult protocols. The purpose of this study is to examine the protocol assignment of older adolescents and its impact on radiation dose to relevant thoracic structures. Materials and Methods: Cooperative group data were reviewed and 12 adolescents were randomly selected from a pediatric HL protocol. Treatment plans were generated per one pediatric and two adult protocols. Dose volume histograms for heart, lung, and breast allowed comparison of radiation dose to these sites across these three protocols. Results: A total of 15.2{\%} of adolescents were treated on adult HL protocols and received significantly higher radiation dosage to heart and lung compared to pediatric HL protocols. Adolescents treated on either pediatric or adult protocols received similar RT dose to breast. Conclusion: Older adolescents treated on adult HL protocols received higher RT dose to thoracic structures except breast. Level of nodal involvement may impact overall RT dose to breast. The impact of varying field design and RT dose on survival, local, and late effects needs further study for this vulnerable age group. Adolescents, young adults, Hodgkin lymphoma, RT, clinical trials.",
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Pieters, RS, Wagner, H, Baker, S, Morano, K, Ulin, K, Cicchetti, MG, Bishop-Jodoin, M & FitzGerald, TJ 2014, 'The impact of protocol assignment for older adolescents with Hodgkin lymphoma', Frontiers in Oncology, vol. 4, no. NOV, 317. https://doi.org/10.3389/fonc.2014.00317

The impact of protocol assignment for older adolescents with Hodgkin lymphoma. / Pieters, Richard S.; Wagner, Henry; Baker, Stephen; Morano, Karen; Ulin, Kenneth; Cicchetti, Maria Giulia; Bishop-Jodoin, Maryann; FitzGerald, Thomas J.

In: Frontiers in Oncology, Vol. 4, No. NOV, 317, 01.01.2014.

Research output: Contribution to journalArticle

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AU - Pieters, Richard S.

AU - Wagner, Henry

AU - Baker, Stephen

AU - Morano, Karen

AU - Ulin, Kenneth

AU - Cicchetti, Maria Giulia

AU - Bishop-Jodoin, Maryann

AU - FitzGerald, Thomas J.

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N2 - Background and Purpose: Hodgkin lymphoma (HL) treatment has evolved to reduce or avoid radiotherapy (RT) dose and volume and minimize the potential for late effects. Some older adolescents are treated on adult protocols. The purpose of this study is to examine the protocol assignment of older adolescents and its impact on radiation dose to relevant thoracic structures. Materials and Methods: Cooperative group data were reviewed and 12 adolescents were randomly selected from a pediatric HL protocol. Treatment plans were generated per one pediatric and two adult protocols. Dose volume histograms for heart, lung, and breast allowed comparison of radiation dose to these sites across these three protocols. Results: A total of 15.2% of adolescents were treated on adult HL protocols and received significantly higher radiation dosage to heart and lung compared to pediatric HL protocols. Adolescents treated on either pediatric or adult protocols received similar RT dose to breast. Conclusion: Older adolescents treated on adult HL protocols received higher RT dose to thoracic structures except breast. Level of nodal involvement may impact overall RT dose to breast. The impact of varying field design and RT dose on survival, local, and late effects needs further study for this vulnerable age group. Adolescents, young adults, Hodgkin lymphoma, RT, clinical trials.

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