The impact of vitamin a deficiency and repletion with retinol and β-carotene on concanavalin a-induced lymphocyte proliferation

S. Sri Kantha, C. E. Taylor, A. Catharine Ross

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Concanavalin A (Con A)-induced splenic lymphocyte proliferation was studied in young rats during vitamin A deficiency and after oral repletion with 1500 retinol equivalents (R.E.) of either retinyl palmitate (RP) or βC-carotene (βC). Initial studies, designed to optimize the proliferation assay, showed that the response of vitamin A-deficient rats was consistently delayed in comparison to control rats fed a vitamin A-adequate diet. The overall magnitude of the proliferative response in vitamin A-deficient rats was also somewhat reduced (≈34% less than that of the control group). After vitamin A-deficient rats were repleted with RP, the Con A-induced proliferative response of splenic lymphocytes resembled that of the control group in both magnitude and kinetics. However, in vitamin A-deficient rats repleted with βC, the delayed response to Con A persisted in some animals and the overall response was intermediate between that of vitamin A-deficient rats and either control rats or rats repleted with RP.

Original languageEnglish (US)
Pages (from-to)1527-1539
Number of pages13
JournalNutrition Research
Volume12
Issue number12
DOIs
StatePublished - Jan 1 1992

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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